Evidence map›Paper›PMID 31578520›Full record

ArticleNature2019

Structure of the inner kinetochore CCAN complex assembled onto a centromeric nucleosome.

Kaige Yan, Jing Yang, Ziguo Zhang, Stephen H McLaughlin, Leifu Chang, Domenico Fasci, Ann E Ehrenhofer-Murray, Albert J R Heck, David Barford

Abstract read
In one paragraph

Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 153 citations in OpenAlex.

  1. Structure and function of the centromere and inner kinetochore.Nature reviews. Molecular cell biology · 2026
    Review
  2. Article
  3. An interdependent Cbf1-CCAN interaction stabilizes the budding yeast kinetochore.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Dual Roads of CENP-A for Centromere Identification.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Structure and dynamics of 2x(CENP-A/H4)Life science alliance · 2026
    Article
  12. Article
  13. Article
  14. Revisiting the question: When is a centromere not a kinetochore?Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Kaige Yan *MRC Laboratory of Molecular Biology, Cambridge, UK.
Jing Yang *MRC Laboratory of Molecular Biology, Cambridge, UK.
Ziguo Zhang *MRC Laboratory of Molecular Biology, Cambridge, UK.
Stephen H McLaughlinMRC Laboratory of Molecular Biology, Cambridge, UK.
Leifu ChangMRC Laboratory of Molecular Biology, Cambridge, UK.
Domenico FasciBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, The Netherlands.
Ann E Ehrenhofer-MurrayHumboldt-Universität zu Berlin, Institut für Biologie, Berlin, Germany.
Albert J R HeckBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, The Netherlands.
David BarfordMRC Laboratory of Molecular Biology, Cambridge, UK. dbarford@mrc-lmb.cam.ac.uk.
MRC Laboratory of Molecular Biology · GBUtrecht University · NLHumboldt-Universität zu Berlin · DEPurdue University West Lafayette · US

Funding

Cancer Research UK 14109Cancer Research UK 24307Cancer Research UK A14109Medical Research Council MC_UP_1201/6
6 · The paper itself

Abstract

In eukaryotes, accurate chromosome segregation in mitosis and meiosis maintains genome stability and prevents aneuploidy. Kinetochores are large protein complexes that, by assembling onto specialized Cenp-A nucleosomes

Indexed as

Centromere Protein ACryoelectron MicroscopyDNAKinetochoresModels, MolecularMultiprotein ComplexesNucleosomesProtein SubunitsSaccharomyces cerevisiaeCentromere Protein ADNAMultiprotein ComplexesNucleosomesProtein Subunits

Identifiers

PMID31578520
PMCPMC6859074
OpenAlexW2978728166

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.