ArticleScientific reports2019
Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Absence of human yaws and detection of Haemophilus ducreyi in skin ulcers of school children near wildlife protected areas in Tanzania.PLoS neglected tropical diseases · 2026Article
- Article
- Whole-genome sequencing reveals evidence for inter-species transmission of the yaws bacterium among nonhuman primates in Tanzania.PLoS neglected tropical diseases · 2025Article
- High prevalence and genetic diversity ofMicrobiology spectrum · 2024Article
- Low genetic diversity of Treponema pallidum ssp. pertenue (TPE) isolated from patients' ulcers in Namatanai District of Papua New Guinea: Local human population is infected by three TPE genotypes.PLoS neglected tropical diseases · 2024Article
- The hare syphilis agent is related to, but distinct from, the treponeme causing rabbit syphilis.PloS one · 2024Article
- The genomes of the yaws bacterium, Treponema pallidum subsp. pertenue, of nonhuman primate and human origin are not genomically distinct.PLoS neglected tropical diseases · 2023Article
- No evidence for yaws infection in a small-scale cross-sectional serosurvey in Ghanaian monkeys.Veterinary medicine and science · 2023Article
- Article
- Penicillin Treatment Failure in Rabbit Syphilis Due to the Persistence of Treponemes (Frontiers in veterinary science · 2021Article
- Geographically structured genomic diversity of non-human primate-infectingMicrobial genomics · 2020Article
- Yaws Disease Caused by Treponema pallidum subspecies pertenue in Wild Chimpanzee, Guinea, 2019.Emerging infectious diseases · 2020Article
- Insights from quantitative and mathematical modelling on the proposed 2030 goals for Yaws.Gates open research · 2019Article
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Authors and funding
17 authors.
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Abstract
In our most recent study, we found that in Tanzania infection with Treponema pallidum (TP) subsp. pertenue (TPE) is present in four different monkey species. In order to gain information on the diversity and epidemiological spread of the infection in Tanzanian nonhuman primates (NHP), we identified two suitable candidate genes for multi-locus sequence typing (MLST). We demonstrate the functionality of the MLST system in invasively and non-invasively collected samples. While we were not able to demonstrate frequent interspecies transmission of TPE in Tanzanian monkeys, our results show a clustering of TPE strains according to geography and not host species, which is suggestive for rare transmission events between different NHP species. In addition to the geographic stability, we describe the relative temporal stability of the strains infecting NHPs and identified multi-strain infection. Differences between TPE strains of NHP and human origin are highlighted. Our results show that antibiotic resistance does not occur in Tanzanian TPE strains of NHP origin.
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