ArticleScientific reports2019
Functional linear modeling of activity data shows analgesic-mediated improved sleep in dogs with spontaneous osteoarthritis pain.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 30 citations in OpenAlex.
- Enhancing meloxicam efficacy in acute and chronic inflammatory pain: a novel dose-sparing approach using ultramicronized palmitoylethanolamide.Inflammopharmacology · 2026Article
- Owner Observed Sleep Disturbances in Cavalier King Charles Spaniels with and Without Clinical Signs Compatible with a Chiari-like Malformation.Animals : an open access journal from MDPI · 2026Article
- A noninferiority trial evaluating the efficacy of bedinvetmab compared to grapiprant for osteoarthritis-pain in dogs using force plate gait analysis.Scientific reports · 2026Article
- Continuous Activity Monitoring Using a Wearable Sensor in Dogs with Osteoarthritis: An Exploratory Case Series.Animals : an open access journal from MDPI · 2025Article
- Actical Accelerometers as a Clinical Tool for the Monitoring of Sleeping and Resting Periods in Individual Dogs.Animals : an open access journal from MDPI · 2025Article
- Physical Activity Monitors in Companion Animal Chronic Pain Research-A Review Focused on Osteoarthritis Pain.Animals : an open access journal from MDPI · 2025Review
- Outcome assessment in veterinary pain studies: a pain in animals workshop (PAW) perspective.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Estimated activity levels in dogs at population scale with linear and causal modeling.Frontiers in veterinary science · 2025Article
- Factors influencing, and associated with, physical activity patterns in dogs with osteoarthritis-associated pain.Frontiers in veterinary science · 2025Article
- Beacon-based sleep-wake monitoring in dogs.The Journal of veterinary medical science · 2024Article
- Cross-sectional and longitudinal analysis of health-related quality of life (HRQoL) in senior and geriatric dogs.PloS one · 2024Article
- Comparative analysis of chronic neuropathic pain and pain assessment in companion animals and humans.Frontiers in veterinary science · 2024Review
- Psychometric Testing and Validation of the Italian Version of the Helsinki Chronic Pain Index (I-HCPI) in Dogs with Pain Related to Osteoarthritis.Animals : an open access journal from MDPI · 2023Article
- Development and validation of a sleep questionnaire, SNoRE 3.0, to evaluate sleep in companion dogs.Scientific reports · 2023Article
- Activity patterns are associated with fractional lifespan, memory, and gait speed in aged dogs.Scientific reports · 2023Article
- Palmitoyl-glucosamine co-micronized with curcumin for maintenance of meloxicam-induced pain relief in dogs with osteoarthritis pain.BMC veterinary research · 2023Article
- COAST Development Group's international consensus guidelines for the treatment of canine osteoarthritis.Frontiers in veterinary science · 2023Review
- A randomized controlled study of a psycho-behavioral intervention combined with a non-benzodiazepine to improve perioperative sleep quality in patients undergoing knee arthroplasty.Frontiers in surgery · 2023Article
- The activity patterns of nonworking and working sled dogs.Scientific reports · 2022Article
- Initial exploration of the discriminatory ability of the PetPace collar to detect differences in activity and physiological variables between healthy and osteoarthritic dogs.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In humans, pain due to osteoarthritis has been demonstrated to be associated with insomnia and sleep disturbances that affect perception of pain, productivity, and quality of life. Dogs, which develop spontaneous osteoarthritis and represent an increasingly used model for human osteoarthritis, would be expected to show similar sleep disturbances. Further, these sleep disturbances should be mitigated by analgesic therapy. Previous efforts to quantify sleep in osteoarthritic dogs using accelerometry have not demonstrated a beneficial effect of analgesic therapy; this is despite owner-reported improvements in dogs' sleep quality. However, analytic techniques for time-series accelerometry data have advanced with the development of functional linear modeling. Our aim was to apply functional linear modeling to accelerometry data from osteoarthritic dogs participating in a cross-over non-steroidal anti-inflammatory (meloxicam) drug trial. Significant differences in activity patterns were seen dogs receiving drug (meloxicam) vs. placebo, suggestive of improved nighttime resting (sleep) and increased daytime activity. These results align with owner-reported outcome assessments of sleep quality and further support dogs as an important translational model with benefits for both veterinary and human health.
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