Evidence map›Paper›PMID 31578422›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2020

Marked variability in intrapartum electronic fetal heart rate patterns: association with neonatal morbidity and abnormal arterial cord gas.

Brock Polnaszek, Julia D López, Reece Clark, Nandini Raghuraman, George A Macones, Alison G Cahill

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06188195 (Establishment and Evaluation of Prenatal Prevention and Treatment Strategy for Neonatal Acute Respiratory Distress Syndrome), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06188195 narecruitingnot on this mapstarted 2024, after this paper: background citation

Establishment and Evaluation of Prenatal Prevention and Treatment Strategy for Neonatal Acute Respiratory Distress Syndrome

TypeinterventionalSponsorThe Second Affiliated Hospital of Chongqing Medical UniversityRan2024 to 2025Enrolled500ConditionsAcute Respiratory Distress Syndrome, Respiratory Distress Syndrome, AcuteArmsDexamethasone
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Increased variability of fetal heart rate during labour: a review of preclinical and clinical studies.BJOG : an international journal of obstetrics and gynaecology · 2022
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Brock PolnaszekDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Washington University in Saint Louis School of Medicine, Saint Louis, MO, USA. brock.polnaszek@wustl.edu.
Julia D LópezDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Washington University in Saint Louis School of Medicine, Saint Louis, MO, USA.ORCID http://orcid.org/0000-0002-8197-002X
Reece ClarkDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Washington University in Saint Louis School of Medicine, Saint Louis, MO, USA.
Nandini RaghuramanDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Washington University in Saint Louis School of Medicine, Saint Louis, MO, USA.
George A MaconesThe University of Texas at Austin Dell Medical School, Austin, TX, USA.
Alison G CahillThe University of Texas at Austin Dell Medical School, Austin, TX, USA.
Washington University in St. Louis · USThe University of Texas at Austin · US

Funding

PREDICTING FETAL ACIDEMIA WITH INTRAPARTUM ELECTRONIC FETAL HEART RATE MONITORINGR01HD061619 · NICHD · WASHINGTON UNIVERSITY · PI CAHILL, ALISON G, MACONES, GEORGE A · 2010 to 2014
$2.9M
NICHD NIH HHS R01 HD061619
6 · The paper itself

Abstract

objectiveInvestigate marked variability in fetal heart rate (FHR) patterns before delivery and its association with neonatal morbidity and abnormal arterial cord gases. STUDY

designProspective cohort of laboring patients at term. Composite neonatal morbidity (respiratory distress, mechanical ventilation, suspected sepsis, meconium aspiration syndrome, therapeutic hypothermia, hypoxic-ischemic encephalopathy, seizure, and death) and abnormal arterial cord gases (pH < 7.10, lactate ≥ 4 mmol/L, base deficit < -12 mEq/L) were assessed with multivariable logistic regression.

resultThree hundred and ninety (4.5%) neonates had marked variability in FHR patterns before delivery. There was no difference in composite neonatal morbidity (aRR 1.22; 95% CI 0.91-1.63), though neonates with marked variability in FHR patterns were more likely to have a respiratory distress (aRR 1.85; 95% CI 1.25-2.70). There was an increased risk of composite abnormal arterial cord gases (aRR 1.66; 95% CI 1.47-1.88).

conclusionMarked variability in FHR patterns was not associated with composite neonatal morbidity but was associated with abnormal arterial cord gases.

Indexed as

BicarbonatesBlood Gas AnalysisCarbon DioxideElectrocardiographyFetal BloodFetal MonitoringHeart Rate, FetalHumansInfant, NewbornInfant, Newborn, DiseasesLactic AcidProspective StudiesBicarbonatesCarbon DioxideLactic Acid

Identifiers

PMID31578422
PMCPMC7202403
OpenAlexW2978735273

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.