ArticleScientific reports2019
Chitin-glucan and pomegranate polyphenols improve endothelial dysfunction.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Improvement of gastrointestinal discomfort and inflammatory status by a synbiotic in middle-aged adults: a double-blind randomized placebo-controlled trial.Scientific reports · 2021Trial
- The Neuroprotective Effect of a Waste Byproduct Obtained From Pomegranate (Punica granatum).Phytotherapy research : PTR · 2026Review
- Alterations of ocular surface microbiome in glaucoma and its association with dry eye.Journal of medical microbiology · 2025Article
- IntratumorCurrent research in microbial sciences · 2025Article
- HFD aggravated the arthritis and atherosclerosis by altering the intestinal status and gut microbiota.Molecular medicine (Cambridge, Mass.) · 2024Article
- The Influence of Polyphenols on Atherosclerosis Development.International journal of molecular sciences · 2023Review
- The Role of Phytochemicals and Gut Microbiome in Atherosclerosis in Preclinical Mouse Models.Nutrients · 2023Review
- The Interplay between Cardiovascular Disease, Exercise, and the Gut Microbiome.Reviews in cardiovascular medicine · 2022Review
- The potential impact of a probiotic: Akkermansia muciniphila in the regulation of blood pressure-the current facts and evidence.Journal of translational medicine · 2022Review
- Beneficial health effects of polyphenols metabolized by fermentation.Food science and biotechnology · 2022Review
- The Effect of Dietary Polyphenols on Vascular Health and Hypertension: Current Evidence and Mechanisms of Action.Nutrients · 2022Review
- Influence of Dissolved Oxygen Level on Chitin-Glucan Complex and Mannans Production by the YeastLife (Basel, Switzerland) · 2022Article
- Natural products against inflammation and atherosclerosis: Targeting on gut microbiota.Frontiers in microbiology · 2022Review
- Cranberry polyphenols and agave agavins impact gut immune response and microbiota composition while improving gut barrier function, inflammation, and glucose metabolism in mice fed an obesogenic diet.Frontiers in immunology · 2022Article
- Urolithins: The Colon Microbiota Metabolites as Endocrine Modulators: Prospects and Perspectives.Frontiers in nutrition · 2021Review
- Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical Applications.Molecules (Basel, Switzerland) · 2020Review
- The Hepatoprotective Effect of Taurisolo, a Nutraceutical Enriched in Resveratrol and Polyphenols, Involves Activation of Mitochondrial Metabolism in Mice Liver.Antioxidants (Basel, Switzerland) · 2020Article
- Synergistic Effects of Natural Product Combinations in Protecting the Endothelium Against Cardiovascular Risk Factors.Journal of evidence-based integrative medicineReview
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vascular dysfunction is the primary event in the occurrence of cardio-vascular risk, and no treatment exists until now. We tested for the first time the hypothesis that chitin-glucan (CG) - an insoluble fibre with prebiotic properties- and polyphenol-rich pomegranate peel extract (PPE) can improve endothelial and inflammatory disorders in a mouse model of cardiovascular disease (CVD), namely by modulating the gut microbiota. Male Apolipoprotein E knock-out (ApoE-/-) mice fed a high fat (HF) diet developed a significant endothelial dysfunction attested by atherosclerotic plaques and increasing abundance of caveolin-1 in aorta. The supplementation with CG + PPE in the HF diet reduced inflammatory markers both in the liver and in the visceral adipose tissue together with a reduction of hepatic triglycerides. In addition, it increased the activating form of endothelial NO-synthase in mesenteric arteries and the heme-nitrosylated haemoglobin (Hb-NO) blood levels as compared with HF fed ApoE-/- mice, suggesting a higher capacity of mesenteric arteries to produce nitric oxide (NO). This study allows to pinpoint gut bacteria, namely Lactobacillus and Alistipes, that could be implicated in the management of endothelial and inflammatory dysfunctions associated with CVD, and to unravel the role of nutrition in the modulation of those bacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.