Evidence map›Paper›PMID 31578392›Full record

ArticleScientific reports2019

The expression of four pyridoxal kinase (PDXK) human variants in Drosophila impacts on genome integrity.

Elisa Mascolo, Anna Barile, Lorenzo Stufera Mecarelli, Noemi Amoroso, Chiara Merigliano, Arianna Massimi, Isabella Saggio, Torben Hansen, Angela Tramonti, Martino Luigi Di Salvo and 3 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. From Fly to Human: Translational Relevance ofInternational journal of molecular sciences · 2026
    Review
  2. International journal of ophthalmology · 2024
    Article
  3. Vitamin BScience advances · 2023
    Article
  4. The Genetics of Diabetes: What We Can Learn fromInternational journal of molecular sciences · 2021
    Review
  5. Review
  6. Review
  7. Functional Inactivation ofInternational journal of molecular sciences · 2021
    Article
  8. Vitamin B6 and Diabetes: Relationship and Molecular Mechanisms.International journal of molecular sciences · 2020 · on this map
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 4 countries.

Elisa MascoloDipartimento di Biologia e Biotecnologie "C. Darwin" Sapienza Università di Roma, Piazzale Aldo Moro 5, 00185, Roma, Italy.
Anna BarileDipartimento di Scienze Biochimiche "A. Rossi Fanelli", Sapienza Università di Roma, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Piazzale Aldo Moro 5, 00185, Roma, Italy.
Lorenzo Stufera MecarelliDipartimento di Biologia e Biotecnologie "C. Darwin" Sapienza Università di Roma, Piazzale Aldo Moro 5, 00185, Roma, Italy.ORCID http://orcid.org/0000-0001-6716-0293
Noemi AmorosoDipartimento di Biologia e Biotecnologie "C. Darwin" Sapienza Università di Roma, Piazzale Aldo Moro 5, 00185, Roma, Italy.
Chiara MeriglianoUniversity of Southern California, Molecular and Computational Biology Department, 1050 Childs Way, Los Angeles, California, 90089, USA.
Arianna MassimiDipartimento di Medicina Sperimentale, Università di Roma Tor Vergata, Via Montpellier 1, 0133, Roma, Italy.
Isabella SaggioDipartimento di Biologia e Biotecnologie "C. Darwin" Sapienza Università di Roma, Piazzale Aldo Moro 5, 00185, Roma, Italy.
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-8748-3831
Angela TramontiDipartimento di Scienze Biochimiche "A. Rossi Fanelli", Sapienza Università di Roma, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Piazzale Aldo Moro 5, 00185, Roma, Italy.
Martino Luigi Di SalvoDipartimento di Scienze Biochimiche "A. Rossi Fanelli", Sapienza Università di Roma, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Piazzale Aldo Moro 5, 00185, Roma, Italy.
Fabrizio BarbettiDipartimento di Medicina Sperimentale, Università di Roma Tor Vergata, Via Montpellier 1, 0133, Roma, Italy.
Roberto ContestabileDipartimento di Scienze Biochimiche "A. Rossi Fanelli", Sapienza Università di Roma, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Piazzale Aldo Moro 5, 00185, Roma, Italy. roberto.constestabile@uniroma1.it.
Fiammetta VernìDipartimento di Biologia e Biotecnologie "C. Darwin" Sapienza Università di Roma, Piazzale Aldo Moro 5, 00185, Roma, Italy. fiammetta.verni@uniroma1.it.ORCID http://orcid.org/0000-0001-8866-3324
Sapienza University of Rome · ITIstituto Pasteur · ITUniversity of Rome Tor Vergata · ITInstitute of Molecular Biology and Pathology · ITNanyang Technological University · SGUniversity of Copenhagen · DKUniversity of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In eukaryotes, pyridoxal kinase (PDXK) acts in vitamin B

Indexed as

AnimalsAnimals, Genetically ModifiedChromosome AberrationsDrosophilaGene Expression Regulation, EnzymologicGenomic InstabilityGlucoseHemolymphHumansLarvaMetabolic Networks and PathwaysMutationPhosphotransferases (Alcohol Group Acceptor)Pyridoxal KinasePyridoxal PhosphateVitamin B 6GlucosePDXK protein, humanPhosphotransferases (Alcohol Group Acceptor)Pyridoxal KinasePyridoxal PhosphateVitamin B 6

Identifiers

PMID31578392
PMCPMC6775053
OpenAlexW2977350602

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.