Evidence map›Paper›PMID 31578390›Full record

ArticleScientific reports2019

Enrichment of hematopoietic stem/progenitor cells in the zebrafish kidney.

Isao Kobayashi, Mao Kondo, Shiori Yamamori, Jingjing Kobayashi-Sun, Makoto Taniguchi, Kaori Kanemaru, Fumihiko Katakura, David Traver

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 46 citations in OpenAlex.

  1. The endothelial scavenger receptorbioRxiv : the preprint server for biology · 2026
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  16. Haematopoiesis in Zebrafish (Danio Rerio).Frontiers in immunology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Isao KobayashiFaculty of Biological Science and Technology, Institute of Science and Engineering, Kanazawa University, Kanazawa, Ishikawa, Japan. ikobayashi@se.kanazawa-u.ac.jp.
Mao KondoDivision of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Ishikawa, Japan.
Shiori YamamoriDivision of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Ishikawa, Japan.
Jingjing Kobayashi-SunDivision of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Ishikawa, Japan.
Makoto TaniguchiDepartment of Life Science, Medical Research Institute, Kanazawa Medical University, Uchinada, Ishikawa, Japan.ORCID http://orcid.org/0000-0001-5920-8285
Kaori KanemaruDepartment of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, Noda, Chiba, Japan.
Fumihiko KatakuraLaboratory of Comparative Immunology, Department of Veterinary Medicine, Nihon University, Fujisawa, Kanagawa, Japan.ORCID http://orcid.org/0000-0002-0156-8533
David TraverDepartment of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-9652-7653
Kanazawa University · JPKanazawa Medical University · JPNihon University · JPTokyo University of Science · JPUniversity of California San Diego · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hematopoietic stem cells (HSCs) maintain the entire blood system throughout life and are utilized in therapeutic approaches for blood diseases. Prospective isolation of highly purified HSCs is crucial to understand the molecular mechanisms underlying regulation of HSCs. The zebrafish is an elegant genetic model for the study of hematopoiesis due to its many unique advantages. It has not yet been possible, however, to purify HSCs in adult zebrafish due to a lack of specific HSC markers. Here we show the enrichment of zebrafish HSCs by a combination of two HSC-related transgenes, gata2a:GFP and runx1:mCherry. The double-positive fraction of gata2a:GFP and runx1:mCherry (gata2a

Indexed as

AnimalsCell DifferentiationCore Binding Factor Alpha 2 SubunitDNA-Binding ProteinsFlow CytometryGATA2 Transcription FactorHematopoiesisHematopoietic Stem CellsKidneyStem CellsTranscriptomeZebrafishZebrafish ProteinsCore Binding Factor Alpha 2 SubunitDNA-Binding ProteinsGata2a protein, zebrafishGATA2 Transcription Factorgfi1ab protein, zebrafishrunx1 protein, zebrafishZebrafish Proteins

Identifiers

PMID31578390
PMCPMC6775131
OpenAlexW2978744642

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.