ArticleScientific reports2019
Site-specific and time-course changes of postmenopausal osteoporosis in rat mandible: comparative study with femur.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 24 citations in OpenAlex.
- Fermentation Time Modulates the Osteoprotective Effects of Milk Kefir in Glucocorticoid-Induced Osteoporotic Rats.Molecular nutrition & food research · 2026Article
- Establishment of artificial intelligence-driven fluorescence morphometry reveals involvement of osteocyte perilacunar remodeling specifically in mandibular bone of ovariectomized rats.Microscopy (Oxford, England) · 2026Article
- Unraveling Jawbone Susceptibility: Distinctive Features Underlying Medication-Related Osteonecrosis.Dentistry journal · 2026Review
- Modeling chronic periodontitis in rats: Persistent alveolar bone loss mediated by periodontal pathogens.Animal models and experimental medicine · 2025Article
- Osteoporosis-Improving Effects of Extracellular Vesicles from Human Amniotic Membrane Stem Cells in Ovariectomized Rats.International journal of molecular sciences · 2025Article
- Magnesium ion hydrogel enhances resistance to radiation-induced bone injury by modulating the bone immune microenvironment and promoting microvascularization.Regenerative biomaterials · 2025Article
- Collagen cross-link profiles and mineral are different between the mandible and femur with site specific response to perturbed collagen.Bone reports · 2022Article
- How relevant is lumbar bone mineral density for the stability of symphyseal implants? A biomechanical cadaver study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Article
- Chronic exposure to lead acetate promotes changes in the alveolar bone of rats: microstructural and physical-chemical characterization.Environmental science and pollution research international · 2022Article
- Evaluation of the effect of vitamin D3 on mandibular condyles in an ovariectomized mouse model: a micro-CT study.BMC oral health · 2021Article
- Is the Jaw Bone Micro-Structure Altered in Response to Osteoporosis and Bisphosphonate Treatment? A Micro-CT Analysis.International journal of molecular sciences · 2021Article
- Acvr1 deletion in osteoblasts impaired mandibular bone mass through compromised osteoblast differentiation and enhanced sRANKL-induced osteoclastogenesis.Journal of cellular physiology · 2021Article
- Curcumin regulates EZH2/Wnt/β-Catenin pathway in the mandible and femur of ovariectomized osteoporosis rats.The Kaohsiung journal of medical sciences · 2021Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the effects of osteoporosis on the skeleton are well studied, site-specific and long-term studies on the mandible are still lacking. This study investigated the time-course changes of the bone microarchitecture in the mandibular condyle in comparison to the corresponding changes in the alveolar bone, body of the mandible, and femur. Thirty-six 11-week-old female Sprague-Dawley rats were divided into ovariectomized (OVX) (24 rats) and sham (12 rats) groups. The right femur and mandible were obtained from 6 OVX rats and 3 sham rats at 8, 12, 26, and 36 weeks after surgery, respectively. The histomorphometric analysis was performed using micro-computed tomography and histologic assessments from the (1) distal femur; (2) the alveolar bone and (3) the body of the mandible; (4) the subchondral and (5) the central region of the condyle. The Brown-Forsythe test was used to verify the assumptions for statistical analysis, and the Mann-Whitney U test was then performed. The mandibular condyle showed increased trabecular bone in both the OVX and sham groups, while the bone density was reduced in the distal femur and the mandible interradicular septum and body. When comparing the OVX group to the sham group, only the central condyle showed a significant reduction in bone density at 36 weeks. Osteoporosis behaves in different manners in different parts of the skeleton, and clinicians should be aware that patients displaying osteoporotic changes in the mandible are expected to show severely advanced bone mineral density reduction in other bones, such as the femur.
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