ArticleNature communications2019
Hydrogen-bonded frameworks for molecular structure determination.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- An Adaptable Porous Metal-Organic Framework for Structural Visualization of Beyond Rule of 5 Molecules on the Microgram Scale.Journal of the American Chemical Society · 2026Article
- Advanced functional porous materials for photocatalytic HChemical science · 2026Review
- Second-Generation Crystalline Sponges Enabling Consistent Structure Analysis Under Standardized Conditions for Diverse Molecules.Angewandte Chemie (International ed. in English) · 2026Article
- Structural Elucidation of Nucleophilic Compounds through Synergistic Coordination and Hydrogen Bonding in a Metal-Organic Framework.Journal of the American Chemical Society · 2025Article
- Single-crystal chiral two-dimensional supramolecular organic frameworks for tunable circularly polarized luminescence.Chemical science · 2025Article
- Hydrogen-bonded organic frameworks for photocatalytic synthesis of hydrogen peroxide.Nature communications · 2025Article
- Intercalation of Neutral Guests in Pillared Salt Cocrystals of 5-Ureidosalyclic Acid.Crystal growth & design · 2025Article
- Hydrogen-bonded frameworks for conformational analysis of reactive substrates.Chemical communications (Cambridge, England) · 2024Article
- Statistical optimization of guest uptake in crystalline sponges: grading structural outcomes.IUCrJ · 2024Article
- Structural Design and Energy and Environmental Applications of Hydrogen-Bonded Organic Frameworks: A Systematic Review.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Host-Guest Cocrystallization of Phenanthrene[2]arene Macrocycles Facilitating Structure Determination of Liquid Organic Molecules.Molecules (Basel, Switzerland) · 2024Article
- Benchmarking Guanidinium Organosulfonate Hydrogen-Bonded Frameworks for Structure Determination of Encapsulated Guests.ACS materials letters · 2024Article
- Supramolecular Mille-Feuille: Adaptive Guest Inclusion in a New Aliphatic Guanidinium Monosulfonate Hydrogen-Bonded Framework.Crystal growth & design · 2024Article
- A molecular T-pentomino for separating BTEX hydrocarbons.Nature communications · 2024Article
- Article
- Steric and Geometrical Frustration Generate Two Higher-Order CuJournal of the American Chemical Society · 2024Article
- Atomic-resolution structure analysis inside an adaptable porous framework.Nature communications · 2024Article
- Superprotonic Conductivity of Guanidinium Organosulfonate Hydrogen-Bonded Organic Frameworks with Nanotube-Shaped Proton Transport Channels.Precision chemistry · 2023Article
- Host-guest system of a phosphorylated macrocycle assisting structure determination of oily molecules in single-crystal form.Chemical science · 2023Article
- 2,4-Dihydroxycinnamic acid as spike ACE2 inhibitor and apigenin as RdRp inhibitor in Nimbamritadi Panchatiktam Kashayam against COVID-19: an in silico and in vitro approach.Molecular diversity · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Single crystal X-ray diffraction is arguably the most definitive method for molecular structure determination, but the inability to grow suitable single crystals can frustrate conventional X-ray diffraction analysis. We report herein an approach to molecular structure determination that relies on a versatile toolkit of guanidinium organosulfonate hydrogen-bonded host frameworks that form crystalline inclusion compounds with target molecules in a single-step crystallization, complementing the crystalline sponge method that relies on diffusion of the target into the cages of a metal-organic framework. The peculiar properties of the host frameworks enable rapid stoichiometric inclusion of a wide range of target molecules with full occupancy, typically without disorder and accompanying solvent, affording well-refined structures. Moreover, anomalous scattering by the framework sulfur atoms enables reliable assignment of absolute configuration of stereogenic centers. An ever-expanding library of organosulfonates provides a toolkit of frameworks for capturing specific target molecules for their structure determination.
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Registered trials
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