Evidence map›Paper›PMID 31578302›Full record

ArticleNeurology2019

Autologous nonmyeloablative hematopoietic stem cell transplantation for neuromyelitis optica.

Richard K Burt, Roumen Balabanov, Xiaoqiang Han, Carol Burns, Joseph Gastala, Borko Jovanovic, Irene Helenowski, Jiraporn Jitprapaikulsan, James P Fryer, Sean J Pittock

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00787722 (Trial of High Dose Immunosuppressive Therapy With Hematopoietic Stem Cell Support in Devic's Disease), which is not on this map. Cited by 51 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 3 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00787722 phase1 / phase2completednot on this map

Trial of High Dose Immunosuppressive Therapy With Hematopoietic Stem Cell Support in Devic's Disease

TypeinterventionalSponsorNorthwestern UniversityRan2009 to 2018Enrolled13ConditionsDevic's DiseaseArmsHematopoietic Stem Cell Transplantation, Cyclophosphamide, G-CSF, rATG, Mesna
3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 3 syntheses or guidelines pooled it, 98 citations in OpenAlex.

  1. Guideline
  2. Guideline
  3. Pooled it
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Advances in the treatment of neuromyelitis optic spectrum disorder.Therapeutic advances in neurological disorders · 2025
    Review
  13. Induction of immune tolerance in NMOSD and MOGAD.Therapeutic advances in neurological disorders · 2025
    Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. The EBMT-ADWP and the CIBMTR.Handbook of clinical neurology · 2024
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Richard K BurtFrom the Division of Immunotherapy, Department of Medicine (R.K.B., X.H., C.B.), and Departments of Neurology (R.B.), Radiology (J.G.), and Preventive Medicine (B.J., I.H.), Northwestern University Feinberg School of Medicine, Chicago, IL; and the Departments of Neurology (J.J., S.J.P.) and Laboratory Medicine and Pathology (J.J., J.P.F., S.J.P.) and Center for Multiple Sclerosis and Autoimmune Neurology (S.J.P.), Mayo Clinic College of Medicine, Rochester, MN. rburt@northwestern.edu.
Roumen BalabanovFrom the Division of Immunotherapy, Department of Medicine (R.K.B., X.H., C.B.), and Departments of Neurology (R.B.), Radiology (J.G.), and Preventive Medicine (B.J., I.H.), Northwestern University Feinberg School of Medicine, Chicago, IL; and the Departments of Neurology (J.J., S.J.P.) and Laboratory Medicine and Pathology (J.J., J.P.F., S.J.P.) and Center for Multiple Sclerosis and Autoimmune Neurology (S.J.P.), Mayo Clinic College of Medicine, Rochester, MN.
Xiaoqiang HanFrom the Division of Immunotherapy, Department of Medicine (R.K.B., X.H., C.B.), and Departments of Neurology (R.B.), Radiology (J.G.), and Preventive Medicine (B.J., I.H.), Northwestern University Feinberg School of Medicine, Chicago, IL; and the Departments of Neurology (J.J., S.J.P.) and Laboratory Medicine and Pathology (J.J., J.P.F., S.J.P.) and Center for Multiple Sclerosis and Autoimmune Neurology (S.J.P.), Mayo Clinic College of Medicine, Rochester, MN.
Carol BurnsFrom the Division of Immunotherapy, Department of Medicine (R.K.B., X.H., C.B.), and Departments of Neurology (R.B.), Radiology (J.G.), and Preventive Medicine (B.J., I.H.), Northwestern University Feinberg School of Medicine, Chicago, IL; and the Departments of Neurology (J.J., S.J.P.) and Laboratory Medicine and Pathology (J.J., J.P.F., S.J.P.) and Center for Multiple Sclerosis and Autoimmune Neurology (S.J.P.), Mayo Clinic College of Medicine, Rochester, MN.
Joseph GastalaFrom the Division of Immunotherapy, Department of Medicine (R.K.B., X.H., C.B.), and Departments of Neurology (R.B.), Radiology (J.G.), and Preventive Medicine (B.J., I.H.), Northwestern University Feinberg School of Medicine, Chicago, IL; and the Departments of Neurology (J.J., S.J.P.) and Laboratory Medicine and Pathology (J.J., J.P.F., S.J.P.) and Center for Multiple Sclerosis and Autoimmune Neurology (S.J.P.), Mayo Clinic College of Medicine, Rochester, MN.ORCID 0000-0001-8792-5302
Borko JovanovicFrom the Division of Immunotherapy, Department of Medicine (R.K.B., X.H., C.B.), and Departments of Neurology (R.B.), Radiology (J.G.), and Preventive Medicine (B.J., I.H.), Northwestern University Feinberg School of Medicine, Chicago, IL; and the Departments of Neurology (J.J., S.J.P.) and Laboratory Medicine and Pathology (J.J., J.P.F., S.J.P.) and Center for Multiple Sclerosis and Autoimmune Neurology (S.J.P.), Mayo Clinic College of Medicine, Rochester, MN.
Irene HelenowskiFrom the Division of Immunotherapy, Department of Medicine (R.K.B., X.H., C.B.), and Departments of Neurology (R.B.), Radiology (J.G.), and Preventive Medicine (B.J., I.H.), Northwestern University Feinberg School of Medicine, Chicago, IL; and the Departments of Neurology (J.J., S.J.P.) and Laboratory Medicine and Pathology (J.J., J.P.F., S.J.P.) and Center for Multiple Sclerosis and Autoimmune Neurology (S.J.P.), Mayo Clinic College of Medicine, Rochester, MN.
Jiraporn JitprapaikulsanFrom the Division of Immunotherapy, Department of Medicine (R.K.B., X.H., C.B.), and Departments of Neurology (R.B.), Radiology (J.G.), and Preventive Medicine (B.J., I.H.), Northwestern University Feinberg School of Medicine, Chicago, IL; and the Departments of Neurology (J.J., S.J.P.) and Laboratory Medicine and Pathology (J.J., J.P.F., S.J.P.) and Center for Multiple Sclerosis and Autoimmune Neurology (S.J.P.), Mayo Clinic College of Medicine, Rochester, MN.ORCID 0000-0003-3342-2755
James P FryerFrom the Division of Immunotherapy, Department of Medicine (R.K.B., X.H., C.B.), and Departments of Neurology (R.B.), Radiology (J.G.), and Preventive Medicine (B.J., I.H.), Northwestern University Feinberg School of Medicine, Chicago, IL; and the Departments of Neurology (J.J., S.J.P.) and Laboratory Medicine and Pathology (J.J., J.P.F., S.J.P.) and Center for Multiple Sclerosis and Autoimmune Neurology (S.J.P.), Mayo Clinic College of Medicine, Rochester, MN.
Sean J PittockFrom the Division of Immunotherapy, Department of Medicine (R.K.B., X.H., C.B.), and Departments of Neurology (R.B.), Radiology (J.G.), and Preventive Medicine (B.J., I.H.), Northwestern University Feinberg School of Medicine, Chicago, IL; and the Departments of Neurology (J.J., S.J.P.) and Laboratory Medicine and Pathology (J.J., J.P.F., S.J.P.) and Center for Multiple Sclerosis and Autoimmune Neurology (S.J.P.), Mayo Clinic College of Medicine, Rochester, MN.
Jisc · GB

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
NCATS NIH HHS UL1 TR001422
6 · The paper itself

Abstract

objectiveTo determine if autologous nonmyeloablative hematopoietic stem cell transplantation (HSCT) could be a salvage therapy for neuromyelitis optica spectrum disorder (NMOSD).

methodsThirteen patients were enrolled in a prospective open-label cohort study (11 NMOSD aquaporin-4-immunoglobulin G [AQP4-IgG]-positive, 1 NMOSD without AQP4, and 1 NMOSD AQP4-IgG-positive with neuropsychiatric systemic lupus erythematosus [SLE]). Following stem cell mobilization with cyclophosphamide (2 g/m

resultsMedian follow-up was 57 months. The patient with coexistent SLE died of complications of active lupus 10 months after HSCT. For the 12 patients with NMOSD without other active coexisting autoimmune diseases, 11 patients are more than 5 years post-transplant, and 80% are relapse-free off all immunosuppression (

conclusionProlonged drug-free remission with AQP4-IgG seroconversion to negative following nonmyeloablative autologous HSCT warrants further investigation.

Indexed as

AdultAntilymphocyte SerumAquaporin 4AutoantibodiesCyclophosphamideFemaleFilgrastimHematologic AgentsHematopoietic Stem Cell MobilizationHematopoietic Stem Cell TransplantationHumansImmunologic FactorsImmunosuppressive AgentsMaleMiddle AgedNeuromyelitis OpticaAntilymphocyte SerumAQP4 protein, humanAquaporin 4AutoantibodiesCyclophosphamideFilgrastimHematologic AgentsImmunologic FactorsImmunosuppressive AgentsRituximabthymoglobulin

Identifiers

PMID31578302
PMCPMC6946475
OpenAlexW2978077412

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.