Evidence map›Paper›PMID 31578290›Full record

ArticleJournal of virology2019

Macromolecular Synthesis Shutoff Resistance by Myeloid Cells Is Critical to IRF7-Dependent Systemic Interferon Alpha/Beta Induction after Alphavirus Infection.

Nishank Bhalla, Christina L Gardner, Sierra N Downs, Matthew Dunn, Chengqun Sun, William B Klimstra

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Sequence Diversity in the 3' Untranslated Region of Alphavirus Modulates IFIT2-Dependent Restriction in a Cell Type-Dependent Manner.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nishank BhallaCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Christina L GardnerCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Sierra N DownsCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Matthew DunnCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Chengqun SunCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
William B KlimstraCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA Klimstra@pitt.edu.
University of Pittsburgh · US

Funding

Molecular Mechanisms of Eastern Equine Encephalitis Virus PathogenesisR01AI095436 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLIMSTRA, WILLIAM B · 2012 to 2022
$4.5M
NIAID NIH HHS R01 AI095436
6 · The paper itself

Abstract

Alphavirus infection of fibroblastic cell types

Indexed as

AlphavirusAlphavirus InfectionsAnimalsCell LineDisease Models, AnimalEncephalitis Virus, Venezuelan EquineFibroblastsHumansInterferon-alphaInterferon-betaInterferon Regulatory Factor-3Interferon Regulatory Factor-7Macromolecular SubstancesMiceMice, KnockoutMyeloid CellsInterferon-alphaInterferon-betaInterferon Regulatory Factor-3Interferon Regulatory Factor-7Irf3 protein, mouseIrf7 protein, mouseMacromolecular Substancesalphavirusinterferonsmacromolecular synthesis shutoffmyeloid cells

Identifiers

PMID31578290
PMCPMC6880179
OpenAlexW2978476750

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.