Evidence map›Paper›PMID 31578289›Full record

ArticleJournal of virology2019

Differentiation into an Effector Memory Phenotype Potentiates HIV-1 Latency Reversal in CD4

Deanna A Kulpa, Aarthi Talla, Jessica H Brehm, Susan Pereira Ribeiro, Sally Yuan, Anne-Gaelle Bebin-Blackwell, Michael Miller, Richard Barnard, Steven G Deeks, Daria Hazuda and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 1 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Human germline biallelic loss-of-functionJournal of human immunity · 2026
    Article
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  15. Article
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  17. Article
  18. CD8Immunity · 2023
    Article
  19. Article
  20. Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Deanna A KulpaDepartment of Pediatrics, Emory University, Atlanta, Georgia, USA deanna.kulpa@emory.edu rafick.sekaly@case.edu.ORCID 0000-0002-0411-7295
Aarthi TallaDepartment of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
Jessica H BrehmViiV Healthcare, Research Triangle Park, North Carolina, USA.
Susan Pereira RibeiroDepartment of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
Sally YuanJanssen Pharmaceuticals, Springhouse, Pennsylvania, USA.
Anne-Gaelle Bebin-BlackwellUniversity of Georgia, Athens, Georgia, USA.
Michael MillerInfectious Disease, Merck & Co., Inc., West Point, Pennsylvania, USA.
Richard BarnardInfectious Disease, Merck & Co., Inc., West Point, Pennsylvania, USA.
Steven G DeeksDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.
Daria HazudaInfectious Disease, Merck & Co., Inc., West Point, Pennsylvania, USA.
Nicolas ChomontCentre de Recherche du CHUM, Montréal, Quebec, Canada.
Rafick-Pierre SékalyDepartment of Pathology, Case Western Reserve University, Cleveland, Ohio, USA deanna.kulpa@emory.edu rafick.sekaly@case.edu.
Case Western Reserve University · USCentre Hospitalier de l’Université de Montréal · CAEmory University · USSpringhouse · USUniversity of California, San Francisco · USUniversity of Georgia · US

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6M
Central memory CD4 T cell infection: key role in ART response and HIV persistenceR01AI110334 · NIAID · EMORY UNIVERSITY · PI MARCONI, VINCENT CHARLES, PAIARDINI, MIRKO · 2013 to 2017
$4.4M
NIAID NIH HHS P30 AI027763NIAID NIH HHS R01 AI110334
6 · The paper itself

Abstract

During antiretroviral therapy (ART), human immunodeficiency virus type 1 (HIV-1) persists as a latent reservoir in CD4

Indexed as

Cell DifferentiationPhenotypeCD4-Positive T-LymphocytesDNA, ViralGene ExpressionHIV-1HIV InfectionsHumansImmunologic MemoryT-Lymphocyte SubsetsVirus LatencyDNA, ViralCD4 T cellsHIV latencyHIV persistence

Identifiers

PMID31578289
PMCPMC6880164
OpenAlexW2978699383

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.