ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Hair Bundle Stimulation Mode Modifies Manifestations of Mechanotransduction Adaptation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- PIPbioRxiv : the preprint server for biology · 2026Article
- A regulatory axis for tonotopic MYO7A expression in cochlear hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The bidirectional interplay between RNA processing and mechanotransduction.Cell reports · 2025Review
- Stereocilium height changes can account for the calcium dependence of the outer-hair-cell bundle's resting state.PloS one · 2025Article
- 3D morphology of an outer-hair-cell hair bundle increases its displacement and dynamic range.Biophysical journal · 2024Article
- The Long Outer-Hair-Cell RC Time Constant: A Feature, Not a Bug, of the Mammalian Cochlea.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- Review
- The impact of targeted ablation of one row of outer hair cells and Deiters' cells on cochlear amplification.Journal of neurophysiology · 2022Article
- cAMP and voltage modulate rat auditory mechanotransduction by decreasing the stiffness of gating springs.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Mechanotransduction in mammalian sensory hair cells.Molecular and cellular neurosciences · 2022Review
- Cy3-ATP labeling of unfixed, permeabilized mouse hair cells.Scientific reports · 2021Article
- In situ motions of individual inner-hair-cell stereocilia from stapes stimulation in adult mice.Communications biology · 2021Article
- Mechanisms in cochlear hair cell mechano-electrical transduction for acquisition of sound frequency and intensity.Cellular and molecular life sciences : CMLS · 2021Review
- Fluid Jet Stimulation of Auditory Hair Bundles Reveal Spatial Non-uniformities and Two Viscoelastic-Like Mechanisms.Frontiers in cell and developmental biology · 2021Article
- Deletion ofFrontiers in cell and developmental biology · 2021Article
- The cochlear ear horn: geometric origin of tonotopic variations in auditory signal processing.Scientific reports · 2020Article
- Manipulation of the Endocochlear Potential Reveals Two Distinct Types of Cochlear Nonlinearity.Biophysical journal · 2020Article
- Decades-old model of slow adaptation in sensory hair cells is not supported in mammals.Science advances · 2020Article
- Myosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex.Nature communications · 2020Article
- Recent advances in cochlear hair cell nanophysiology: subcellular compartmentalization of electrical signaling in compact sensory cells.Faculty reviews · 2020Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Sound detection in auditory sensory hair cells depends on the deflection of the stereocilia hair bundle which opens mechano-electric transduction (MET) channels. Adaptation is hypothesized to be a critical property of MET that contributes to the auditory system's wide dynamic range and sharp frequency selectivity. Our recent work using a stiff probe to displace hair bundles showed that the fastest adaptation mechanism (fast adaptation) does not require calcium entry. Using fluid-jet stimuli, others obtained data showing only a calcium-dependent fast adaptation response. Because cochlear stereocilia do not move coherently and the hair cell response depends critically on the magnitude and time course of the hair bundle deflection, we developed a high-speed imaging technique to quantify this deflection in rat cochlear hair cells. The fluid jet delivers a force stimulus, and force steps lead to a complex time course of hair bundle displacement (mechanical creep), which affects the hair cell's macroscopic MET current response by masking the time course of the fast adaptation response. Modifying the fluid-jet stimulus to generate a hair bundle displacement step produced rapidly adapting currents that did not depend on membrane potential, confirming that fast adaptation does not depend on calcium entry. MET current responses differ with stimulus modality and will shape receptor potentials of different hair cell types based on their
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.