Evidence map›Paper›PMID 31578230›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Heterosynaptic GABA

Kevin M Manz, Andrew G Baxley, Zack Zurawski, Heidi E Hamm, Brad A Grueter

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Pre- and Post-synaptic Mechanisms of Neuronal Inhibition Assessed Through Biochemically Detailed Modeling of GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Distinct mechanisms of CB1 and GABAThe Journal of physiology · 2023
    Article
  8. SNAP25 differentially contributes to GFrontiers in cellular neuroscience · 2023
    Article
  9. Article
  10. Keeping the Balance: GABABrain sciences · 2022
    Review
  11. Synaptic Integration of Subquantal Neurotransmission by Colocalized G Protein-Coupled Receptors in Presynaptic Terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  12. Cocaine restricts nucleus accumbens feedforward drive through a monoamine-independent mechanism.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
  13. Review
  14. GABACurrent topics in behavioral neurosciences · 2022
    Review
  15. Kappa opioid receptor modulation of excitatory drive onto nucleus accumbens fast-spiking interneurons.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Article
  16. Review
  17. Article
  18. Axo-axonic synapses: Diversity in neural circuit function.The Journal of comparative neurology · 2021
    Review
  19. Noradrenergic Signaling Disengages Feedforward Transmission in the Nucleus Accumbens Shell.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  20. Neurexins regulate presynaptic GABANature communications · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Kevin M ManzMedical Scientist Training Program.
Andrew G BaxleyCollege of Arts and Sciences.
Zack ZurawskiDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232.
Heidi E HammDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232.ORCID 0000-0001-5437-5287
Brad A GrueterDepartment of Anesthesiology, brad.grueter@vumc.org.ORCID 0000-0002-4224-3866
Vanderbilt University · USAllen Institute for Brain Science · USBioscience Research · UST.K.M. College of Arts and Science

Funding

Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DYKENS, ELISABETH MAY · 2015 to 2019
$7.1M
Parvalbumin interneurons regulate nucleus accumbens synapses and behaviorR01DA040630 · NIDA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GRUETER, BRAD ALAN · 2016 to 2025
$4.5M
NICHD NIH HHS U54 HD083211NIDA NIH HHS R01 DA040630
6 · The paper itself

Abstract

Complex circuit interactions within the nucleus accumbens (NAc) facilitate goal-directed behavior. Medium spiny neurons (MSNs) mediate NAc output by projecting to functionally divergent brain regions, a property conferred, in part, by the differential projection patterns of D1- and D2 dopamine receptor-expressing MSNs. Glutamatergic afferents to the NAc direct MSN output by recruiting feedforward inhibitory microcircuits comprised of parvalbumin (PV)-expressing interneurons (INs). Furthermore, the GABA

Indexed as

AnimalsGABA-B Receptor AgonistsGlutamic AcidMaleMiceMice, Inbred C57BLMice, TransgenicNerve NetNucleus AccumbensOrgan Culture TechniquesReceptors, GABA-BSynapsesSynaptic TransmissionGABA-B Receptor AgonistsGlutamic AcidReceptors, GABA-Bfeedforward inhibitionGABABnucleus accumbensparvalbumin interneuronssynaptic plasticity

Identifiers

PMID31578230
PMCPMC6867813
OpenAlexW2978222760

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.