Evidence map›Paper›PMID 31578206›Full record

ArticleDrug metabolism and disposition: the biological fate of chemicals2019

Role of l- and d-Menthol in the Glucuronidation and Detoxification of the Major Lung Carcinogen, NNAL.

Shannon Kozlovich, Gang Chen, Christy J W Watson, William J Blot, Philip Lazarus

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug metabolism and disposition: the biological fate of chemicals, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Molecules (Basel, Switzerland) · 2022
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Shannon KozlovichDepartment of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (S.K., G.C., C.J.W.W., P.L.); and Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee (W.J.B.).ORCID 0000-0002-8900-6382
Gang ChenDepartment of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (S.K., G.C., C.J.W.W., P.L.); and Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee (W.J.B.).ORCID 0000-0002-4353-3806
Christy J W WatsonDepartment of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (S.K., G.C., C.J.W.W., P.L.); and Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee (W.J.B.).
William J BlotDepartment of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (S.K., G.C., C.J.W.W., P.L.); and Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee (W.J.B.).
Philip LazarusDepartment of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (S.K., G.C., C.J.W.W., P.L.); and Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee (W.J.B.) phil.lazarus@wsu.edu.
Washington State University Spokane · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8M
Southern Community Cohort StudyR01CA092447 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., ZHENG, WEI · 2001 to 2015
$74.0M
Southern Community Cohort StudyU01CA202979 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., SHRUBSOLE, MARTHA J. · 2016 to 2025
$22.0M
The UGT2A and 3A metabolizing enzymes and tobacco-related cancer riskR01ES025460 · NIEHS · WASHINGTON STATE UNIVERSITY · PI LAZARUS, PHILIP · 2015 to 2019
$2.8M
NCI NIH HHS P30 CA068485NCI NIH HHS R01 CA092447NCI NIH HHS U01 CA202979NIEHS NIH HHS R01 ES025460
6 · The paper itself

Abstract

Menthol, which creates mint flavor and scent, is often added to tobacco in both menthol and nonmenthol cigarettes. A potent tobacco carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), is extensively metabolized to its equally carcinogenic metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) as (

Indexed as

CarcinogensCohort StudiesGlucuronidesGlucuronosyltransferaseHEK293 CellsHumansMentholMicrosomes, LiverNitrosaminesSmokingStereoisomerismTobacco ProductsTransfection4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol N-glucuronideCarcinogensGlucuronidesGlucuronosyltransferaseMentholNitrosamines

Identifiers

PMID31578206
PMCPMC7031765
OpenAlexW2978051638

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.