Evidence map›Paper›PMID 31578205›Full record

Trial reportBlood2019

The poor outcome in high molecular risk, hydroxycarbamide-resistant/intolerant ET is not ameliorated by ruxolitinib.

Jennifer M O'Sullivan, Angela Hamblin, Christina Yap, Sonia Fox, Rebecca Boucher, Anesh Panchal, Samah Alimam, Helene Dreau, Kieran Howard, Pauline Ware and 4 more

Abstract readLetterRandomized Controlled Trial
In one paragraph

Trial report in Blood, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Article
  3. Molecular profiling in MPN: who should have it and why?Hematology. American Society of Hematology. Education Program · 2024
    Review
  4. The role of TET2 in solid tumors and its therapeutic potential: a comprehensive review.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Review
  5. Review
  6. The Prevalence ofCancers · 2021
    Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jennifer M O'SullivanDepartment of Haematology, Guy's and St. Thomas' National Health Service (NHS) Foundation Trust, London, United Kingdom.
Angela HamblinOxford Molecular Diagnostics Centre, Oxford, United Kingdom.
Christina YapCancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom.
Sonia FoxCancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom.
Rebecca BoucherCancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom.
Anesh PanchalCancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom.
Samah AlimamDepartment of Haematology, Guy's and St. Thomas' National Health Service (NHS) Foundation Trust, London, United Kingdom.
Helene DreauOxford Molecular Diagnostics Centre, Oxford, United Kingdom.
Kieran HowardOxford Molecular Diagnostics Centre, Oxford, United Kingdom.
Pauline WareOxford Molecular Diagnostics Centre, Oxford, United Kingdom.
Nicholas C P CrossWessex Regional Genetics Laboratory, Salisbury, United Kingdom; and.
Mary Frances McMullinDepartment of Haematology, Queen's University, Belfast, United Kingdom.
Claire N HarrisonDepartment of Haematology, Guy's and St. Thomas' National Health Service (NHS) Foundation Trust, London, United Kingdom.
Adam J MeadHaematopoietic Stem Cell Biology Laboratory and.

Funding

Cancer Research UK 25354Cancer Research UK C22436/A25354Medical Research Council MC_UU_12009/5Medical Research Council MR/L006340/1Medical Research Council MR/S001190/1
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Drug ResistanceHydroxyureaThrombocythemia, EssentialDisease-Free SurvivalFemaleHumansMaleNitrilesPyrazolesPyrimidinesRisk FactorsSurvival RateHydroxyureaNitrilesPyrazolesPyrimidinesruxolitinib

Identifiers

PMID31578205
PMCPMC6917505

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.