ReviewComparative medicine2019
Analytic and Interpretational Pitfalls to Measuring Fecal Corticosterone Metabolites in Laboratory Rats and Mice.
Review in Comparative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Corticosterone Under Experimental Manipulation of Nutrition and Parasite Burden in a Wild Rodent System.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2026Article
- Repeated restraint stress-induced increase in post-surgical somatosensory hypersensitivity and affective responding is mediated by β-adrenergic receptor activation and spinal NLRP3-IL1β signalling in male rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Shelved cages impact affective behavior in Sprague Dawley rats - implications for animal welfare.Laboratory animals · 2026Article
- Breathing Rate as a Marker for Noise-Induced Stress in Guinea Pigs.Brain sciences · 2025Article
- Rearing in a Shelved Environment Chronically Modifies Offspring Behaviour and Physiology.The European journal of neuroscience · 2025Article
- Use of fecal microbiome to understand the impact of housing conditions on metabolic stress responses in farmed saltwater crocodiles (Frontiers in veterinary science · 2025Article
- A non-invasive approach to awake mouse fMRI compatible with multi-modal techniques.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Non-Invasive Monitoring of Corticosterone Levels in Mouse Urine with Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry.Molecules (Basel, Switzerland) · 2024Article
- Experience of Euclidean geometry sculpts the development and dynamics of rodent hippocampal sequential cell assemblies.Nature communications · 2024Article
- Individualized Housing Modifies the Immune-Endocrine System in CD1 Adult Male Mice.Animals : an open access journal from MDPI · 2023Article
- A meta-analysis of randomized controlled studies on the hepatoxicity induced by polybrominated diphenyl ethers (PBDEs) in rats and mice.Current research in toxicology · 2023Article
- Meta-analysis reveals between-population differences affect the link between glucocorticoids and population health.Conservation physiology · 2023Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Minimization and alleviation of stress are generally viewed as desirable aspects of laboratory animal management and use. However, achieving that goal requires an unambiguous and valid measure of stress. Glucocorticoid concentrations are commonly used as a physiologic index of stress. Measurement of glucocorticoids in blood, serum or plasma clearly reflects many types of both acute and chronic stress. However, the rapid rise in concentrations of circulating glucocorticoids that occurs even with relatively simple manipulations such as handling has led to the increased use of fecal glucocorticoid metabolite (FCM) assays, which provide a temporally integrated measure that may allow a more accurate interpretation of chronic stressors. In this review, we consider 3 aspects of glucocorticoids as a measure of stress. First, we discuss the analytic and interpretational pitfalls of using FCM concentrations as an index of stress in mice and rats. Second, we consider evidence that some degree of stress may benefit animals by priming physiologic and behavioral adaptations that render the animals more resilient in the face of stress. Finally, we use 2 situations-social housing and food restriction-to illustrate the concept of hormesis-a biologic phenomenon in which a low dose or intensity of a challenge has a beneficial effect, whereas exposure to high doses or intensities is detrimental.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.