Evidence map›Paper›PMID 31578032›Full record

ArticlePediatric research2020

Increased expression of heme oxygenase-1 suppresses airway branching morphogenesis in fetal mouse lungs exposed to inflammation.

Yukio Arai, Masato Ito, Kosuke Tanaka, Junichi Ozawa, Yukiko Motojima, Kikumi Matsuoka, Kazuhiko Igarashi, Fumihiko Namba

Erratum issuedOpen access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Pediatric research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yukio AraiDepartment of Pediatrics, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, 350-8550, Japan.
Masato ItoDepartment of Pediatrics, Akita University Graduate School of Medicine, Akita, Akita, 010-8543, Japan.
Kosuke TanakaDepartment of Pediatrics, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, 350-8550, Japan.
Junichi OzawaDepartment of Pediatrics, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, 350-8550, Japan.
Yukiko MotojimaDepartment of Pediatrics, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, 350-8550, Japan.
Kikumi MatsuokaDepartment of Pediatrics, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, 350-8550, Japan.
Kazuhiko IgarashiDepartment of Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8575, Japan.
Fumihiko NambaDepartment of Pediatrics, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, 350-8550, Japan. nambaf@saitama-med.ac.jp.ORCID http://orcid.org/0000-0001-6137-4477
Social Insurance Saitama Chuo Hospital · JPAkita University · JPTohoku University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntrauterine inflammation affects fetal lung development. BTB and CNC homology 1 (Bach1) is a transcriptional repressor of heme oxygenase-1 (HO-1) and interleukin-6 (IL-6) genes. We investigated the role of Bach1 in the development of fetal mouse lungs exposed to lipopolysaccharide (LPS) using a whole fetal lung tissue culture system.

methodsWe isolated and cultured embryonic day 12.5 fetal mouse lungs from pregnant Bach1 knockout (

resultsBranching morphogenesis was observed in Bach1

conclusionThe ablation of Bach1 suppresses airway branching morphogenesis after LPS exposure by increased basal expression levels of HO-1.

Indexed as

AnimalsBasic-Leucine Zipper Transcription FactorsFemaleGene Expression Regulation, DevelopmentalHeme Oxygenase-1Interleukin-6LipopolysaccharidesLungMembrane ProteinsMice, Inbred C57BLMice, KnockoutMorphogenesisOrgan Culture TechniquesPneumoniaPregnancySignal TransductionBACH1 protein, humanBasic-Leucine Zipper Transcription FactorsHeme Oxygenase-1Hmox1 protein, mouseInterleukin-6interleukin-6, mouselipopolysaccharide, E coli O55-B5LipopolysaccharidesMembrane Proteins

Identifiers

PMID31578032
OpenAlexW2978897239

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.