Evidence map›Paper›PMID 31577948›Full record

ArticleCell reports2019

The Pseudomonas aeruginosa T6SS Delivers a Periplasmic Toxin that Disrupts Bacterial Cell Morphology.

Thomas E Wood, Sophie A Howard, Andreas Förster, Laura M Nolan, Eleni Manoli, Nathan P Bullen, Hamish C L Yau, Abderrahman Hachani, Richard D Hayward, John C Whitney and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 128 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Type VI Secretion Systems inMicroorganisms · 2026
    Article
  5. Article
  6. Review
  7. The SPI-20 and SPI-21 T6SS gene clusters fromFrontiers in microbiology · 2026
    Article
  8. The SPI-6 T6SS gene cluster fromFrontiers in microbiology · 2026
    Article
  9. Virulence · 2025
    Article
  10. Article
  11. Article
  12. Deciphering theJournal of bacteriology · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. TheISME communications · 2025
    Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Thomas E WoodMRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London SW7 2AZ, UK.
Sophie A HowardMRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London SW7 2AZ, UK.
Andreas FörsterSection of Structural Biology, Department of Medicine, Imperial College London, London SW7 2AZ, UK.
Laura M NolanMRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London SW7 2AZ, UK.
Eleni ManoliMRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London SW7 2AZ, UK.
Nathan P BullenMichael DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S 4K1, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada.
Hamish C L YauCentre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Abderrahman HachaniMRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London SW7 2AZ, UK.
Richard D HaywardDivision of Microbiology and Parasitology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK.
John C WhitneyMichael DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S 4K1, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada.
Waldemar VollmerCentre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Paul S FreemontSection of Structural Biology, Department of Medicine, Imperial College London, London SW7 2AZ, UK.
Alain FillouxMRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London SW7 2AZ, UK. Electronic address: a.filloux@imperial.ac.uk.
Imperial College London · GBMcMaster University · CANewcastle University · GBUniversity of Cambridge · GB

Funding

Biotechnology and Biological Sciences Research Council BB/N002539/1Medical Research Council G0800171Medical Research Council MR/K001930/1Medical Research Council MR/N023250/1Medical Research Council MR/P028225/1Medical Research Council MR/S02316X/1Wellcome Trust
6 · The paper itself

Abstract

The type VI secretion system (T6SS) is crucial in interbacterial competition and is a virulence determinant of many Gram-negative bacteria. Several T6SS effectors are covalently fused to secreted T6SS structural components such as the VgrG spike for delivery into target cells. In Pseudomonas aeruginosa, the VgrG2b effector was previously proposed to mediate bacterial internalization into eukaryotic cells. In this work, we find that the VgrG2b C-terminal domain (VgrG2b

Indexed as

Anti-Bacterial AgentsBacterial ProteinsBacterial Secretion Systemsbeta-LactamsPeriplasmPseudomonas aeruginosaType VI Secretion SystemsVirulence FactorsAnti-Bacterial AgentsBacterial ProteinsBacterial Secretion Systemsbeta-LactamsType VI Secretion SystemsVirulence FactorseffectormetallopeptidasePseudomonas aeruginosatype VI secretion systemVgrG

Identifiers

PMID31577948
PMCPMC6899460
OpenAlexW2978088979

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.