Evidence map›Paper›PMID 31577933›Full record

ReviewCell metabolism2019

NAD

Sofie Lautrup, David A Sinclair, Mark P Mattson, Evandro F Fang

3 registry-linked trialsOpen access · bronzeAbstract readReview
In one paragraph

Review in Cell metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 469 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
469citing papers in PubMed, 4 pooled it
37.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05522179 nacompletednot on this mapstarted 2022, after this paper: background citation

Nutritional Supplements to Support Recovery After Foot Surgery - A Pilot Study

TypeinterventionalSponsorNutraHealRan2022 to 2023Enrolled46ConditionsFoot Injuries and DisordersArmsNutraHeal, NutraHeal Plus
NCT06324877 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Single Arm Open-label Clinical Trial in Ataxia-telangiectasia to Test the Effects of Nicotinamide Riboside on Ataxia Scales, Immune Function, and Neurofilament Light Chain.

TypeinterventionalSponsorThe University of QueenslandRan2024 to 2025Enrolled10ConditionsAtaxia TelangiectasiaArmsNicotinamide riboside
NCT06991712 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Comparisons of Nicotinamide Adenine Dinucleotide (NAD) Precursors for Neuroenhancement in Glaucoma Patients

TypeinterventionalSponsorChristopher Kai Shun LeungRan2025 to 2026Enrolled138ConditionsGlaucomaArmsNicotinamide Riboside, Nicotinamide, Nicotinamide Mononucleotide, Nicotinic Acid, Placebo (Corn Starch)
3 · Its place in the literature

Who cites it

469 citing papers in PubMed, 4 syntheses or guidelines pooled it, 722 citations in OpenAlex.

  1. Pooled it
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  9. SIRT1 in Neurodegenerative Diseases: Molecular Mechanisms, Disease Relevance, and Therapeutic Potential.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
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  20. Metallothionein and neurodegenerative diseases.Neural regeneration research · 2026
    Article

409 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

Sofie LautrupDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478 Lørenskog, Norway.
David A SinclairDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA; Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
Mark P MattsonDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Evandro F FangDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478 Lørenskog, Norway; The Norwegian Centre on Healthy Ageing (NO-Age), Oslo, Norway. Electronic address: e.f.fang@medisin.uio.no.
Akershus University Hospital · NOJohns Hopkins Medicine · USUniversity of Oslo · NOUNSW Sydney · AU

Funding

Uncovering the Human SecretomeDP1AG058605 · NIA · HARVARD MEDICAL SCHOOL · PI SINCLAIR, DAVID A. · 2017 to 2021
$5.9M
Role of Sgs1 DNA helicase in telomere maintenanceR01AG019719 · NIA · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI SINCLAIR, DAVID A. · 2001 to 2022
$5.3M
SIRT1 as a regulator of health and lifespan of mammalsR37AG028730 · NIA · HARVARD MEDICAL SCHOOL · PI SINCLAIR, DAVID A. · 2012 to 2021
$4.1M
Elucidating mechanisms of SIRT1 activationR01DK100263 · NIDDK · HARVARD MEDICAL SCHOOL · PI SINCLAIR, DAVID A. · 2016 to 2020
$2.5M
Nicotinamide Mononucleotide (NMN) as a Novel Therapeutic in the Treatment of Oral MucositisR21DE027490 · NIDCR · HARVARD MEDICAL SCHOOL · PI SINCLAIR, DAVID A. · 2018 to 2019
$466k
NIA NIH HHS DP1 AG058605NIA NIH HHS R01 AG019719NIA NIH HHS R37 AG028730NIDCR NIH HHS R21 DE027490NIDDK NIH HHS R01 DK100263
6 · The paper itself

Abstract

NAD

Indexed as

AgingAnimalsBrainCell LineHumansMiceNADNeurodegenerative DiseasesNeuronsRatsNADAlzheimer’s diseasebrain agingmitochondriamitophagyNAD+neurodegenerationneuronal plasticityParkinson’s diseasesirtuins

Identifiers

PMID31577933
PMCPMC6787556
OpenAlexW2977367243

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.