Evidence map›Paper›PMID 31577929›Full record

ArticleCell metabolism2019

Bone Marrow: An Immunometabolic Refuge during Energy Depletion.

Emily L Goldberg, Vishwa Deep Dixit

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Dietary Regulation of Memory T Cells.International journal of molecular sciences · 2020
    Review
  9. Positive Effect of Gushukang on Type-H Vessel and Bone Formation.Frontiers in cell and developmental biology · 2020
    Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Emily L GoldbergDepartment of Comparative Medicine, Yale School of Medicine, New Haven, CT 06520, USA; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA.
Vishwa Deep DixitDepartment of Comparative Medicine, Yale School of Medicine, New Haven, CT 06520, USA; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA; Yale Center for Research on Aging, Yale School of Medicine, New Haven, CT 06520, USA. Electronic address: vishwa.dixit@yale.edu.

Funding

The role of AgRP/Auga-ALK pathway in FGF21's brain action on agingP01AG051459 · NIA · YALE UNIVERSITY · PI VISHWA DEEP DIXIT · 2016 to 2026
$25.7M
Thymic adipogenesis and age-related thymic demiseR01AI105097 · NIAID · YALE UNIVERSITY · PI DIXIT, VISHWA DEEP · 2015 to 2018
$1.9M
Impact of Ketone Metabolites on Inflammasome Deactivation in GoutR01AR070811 · NIAMS · YALE UNIVERSITY · PI DIXIT, VISHWA DEEP · 2017 to 2021
$1.8M
Inflammasomes and the mechanism of thymic demise in agingR01AG043608 · NIA · YALE UNIVERSITY · PI DIXIT, VISHWA DEEP · 2013 to 2017
$1.8M
Impact of ketone bodies on age-related inflammation and healthspan extensionK99AG058801 · NIA · YALE UNIVERSITY · PI GOLDBERG, EMILY LAUREN · 2019 to 2020
$203k
NIAID NIH HHS R01 AI105097NIAMS NIH HHS R01 AR070811NIA NIH HHS K99 AG058801NIA NIH HHS P01 AG051459NIA NIH HHS R01 AG043608
6 · The paper itself

Abstract

An integrated immunometabolic response during negative energy balance is required for host survival. Three new papers by Jordan et al. (2019), Nagai et al. (2019), and Collins et al. (2019) report that monocytes, naive B cells, and memory CD8 T cells use bone marrow as a haven to tide off periods of metabolic adversity to maintain immune-responsiveness.

Indexed as

Bone MarrowImmunity, MucosalBone Marrow CellsFastingMonocytesT-Lymphocytes

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.