ArticlePloS one2019
Early mortality after diagnosis of cancer of the head and neck - A population-based nationwide study.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Early and late mortality among patients with T1-T3 head and neck squamous cell carcinoma: a machine learning analysis using a SEER population-based cohort study.Scientific reports · 2026Article
- Machine learning for survival outcome in head and neck squamous cell carcinoma: a multicenter validation study.Scientific reports · 2025Observational
- Risk factors for early mortality and impaired quality of life in oral cavity cancer - head and neck cancer register study.Acta oncologica (Stockholm, Sweden) · 2025Article
- The Utilization of Specialist Palliative Care and Other Health Care Services at the End of Life Among Patients with Head and Neck Cancer: A Nationwide Cohort Study.Oncology and therapy · 2025Article
- Risk of early death after treatment with curative intent for head and neck squamous cell carcinoma: a retrospective population-based study.Acta oncologica (Stockholm, Sweden) · 2025Article
- Modified Textbook Outcome was a Predictor for Early Mortality After Oral Cancer Surgery.Annals of surgical oncology · 2025Article
- Article
- Imaging-based evaluation of cervical muscle mass and 6-month survival in males with hypopharyngeal carcinoma.Acta oncologica (Stockholm, Sweden) · 2024Article
- Curcumin: A Potential Weapon in the Prevention and Treatment of Head and Neck Cancer.ACS pharmacology & translational science · 2024Review
- Six-month mortality has decreased for patients with curative treatment intent for head and neck cancer in Sweden.PloS one · 2024Article
- Clinical characteristics and outcomes of persistent bacteremia in patients with head and neck cancer in a tertiary care hospital.Frontiers in medicine · 2024Article
- Post-Radiotherapy Exosomal Non-Coding RNA and Hemograms for Early Death Prediction in Patients with Cervical Cancer.International journal of molecular sciences · 2023Article
- Higher Risk of Recurrence in Patients Treated for Head and Neck Cancer with Low BMI and Elevated Levels of C-Reactive Protein.Cancers · 2022Article
- Article
- Mortality during In-Hospital Treatment for Head and Neck Cancer in Germany: A Diagnosis-Related Group-Based Nationwide Analysis, 2005-2018.Journal of oncology · 2022Article
- Biological roles and clinical significance of estrogen and androgen receptors in head and neck cancers.Journal of Cancer · 2022Review
- Bloodstream infections in head and neck cancer patients after curative-intent radiotherapy: a population-based study from the Danish Head and Neck Cancer Group database.British journal of cancer · 2021Article
- A Nordic survey of the management of palliative care in patients with head and neck cancer.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Effectiveness and safety of nivolumab in patients with head and neck cancer in Japanese real-world clinical practice: a multicenter retrospective clinical study.International journal of clinical oncology · 2021Article
- Incidence and Survival for Head and Neck Cancers in Estonia, 1996-2016: A Population-Based Study.Clinical epidemiology · 2021Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCancers of the head and neck have a high mortality rate, and roughly 10% of the patients die within six months of diagnosis. To our knowledge little has been written about this group. We wished to identify risk factors for early death, to predict and monitor patients at risk better and, if possible, avoid unjustified major treatment. METHODS AND
findingsThis population-based nationwide study from the Swedish Head and Neck Cancer Register (SweHNCR) included data from 2008-2015 and 9733 patients at potential risk of early death. A total of 925 (9.5%) patients died within six months. For every year older the patients became, the risk of early death increased by 2.3% (p<0.001). The relative risk of death was 3.37 times higher (237%) for patients with WHO score 1 compared with WHO score 0. A primary tumour in the hypopharynx correlated with a 24% increased risk over the oral cavity (p<0.024). Patients with stage IV disease had a 3.7 times greater risk of early death than those with stage I (p<0.001). As expected, a 12 times increased risk of early death was noted in the palliative treatment group, compared to the curative group. Limitations to this study were that the actual cause of death was not recorded in the SweHNCR, and that socioeconomic factors, alcohol consumption, smoking habits, and HPV status, were not reported in SweHNCR until 2015. However, the fact that this is a population-based nationwide study including 9733 patients compensates for some of these limitations.
conclusionsIdentification of patients at increased risk of early death shows that older patients with advanced disease, increased WHO score, primary tumour in the hypopharynx, and those given palliative treatment, are more likely than the others to die from head and neck cancer within six months of diagnosis.
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