ArticlePloS one2019
Comparison of long-term outcomes between enteral nutrition via gastrostomy and total parenteral nutrition in older persons with dysphagia: A propensity-matched cohort study.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Incidence of dysphagia-related safety incidents in older adults across feeding methods: A systematic review and meta-analysis.The journal of nutrition, health & aging · 2025Pooled it
- A systematic review on dysphagia treatments for persons living with dementia.European geriatric medicine · 2024Pooled it
- Enteral tube feeding for people with severe dementia.The Cochrane database of systematic reviews · 2021Pooled it
- Comparing central venous access strategies in elderly patients with dysphagia: a survival analysis.Frontiers in nutrition · 2026Article
- Prognostic value of the lymphocyte-to-C-reactive protein ratio for mortality in geriatric patients with severe dysphagia requiring artificial nutrition: a retrospective secondary analysis.Frontiers in medicine · 2026Article
- Hemoglobin predicts mortality risk in geriatric patients with dysphagia: a Japanese retrospective cohort study.Frontiers in nutrition · 2026Article
- Day-7 caloric intake as an early dynamic prognostic marker for subsequent mortality in older patients with dysphagia: a landmark cohort analysis.Frontiers in nutrition · 2026Article
- Age and sex adjusted adiposity estimators predict all cause and pneumonia related mortality in hospitalized older patients with severe dysphagia receiving artificial nutrition.Frontiers in nutrition · 2026Article
- Negative association of hemoglobin levels with mortality in older Japanese patients with dysphagia: a retrospective cohort study.Frontiers in medicine · 2026Article
- Importance of Enteral Feeding: Enhancing Patient Care through Interventional Radiology.Seminars in interventional radiology · 2025Review
- Prognostic nutritional index negative associated with mortality in older Japanese patients with dysphagia.Frontiers in nutrition · 2025Article
- Albumin-related nutritional indices and all-cause and cause-specific mortality in older adults with severe dysphagia receiving artificial feeding.Frontiers in nutrition · 2025Article
- Association of the lymphocyte-to-C-reactive protein ratio with long-term mortality in hospitalized older adults with severe dysphagia.Frontiers in nutrition · 2025Article
- C-reactive protein-albumin-lymphocyte (CALLY) index predicts overall survival in elderly Japanese patients with dysphagia: a retrospective cohort study.Frontiers in nutrition · 2025Article
- Association between controlling nutritional status score and mortality in older patients with dysphagia in Japan:Frontiers in nutrition · 2025Article
- Association between C-reactive protein/albumin ratio and mortality in older Japanese patients with post-stroke dysphagia.Frontiers in neurology · 2025Article
- Correlation between controlling nutritional status score and mortality risk in older Japanese adults diagnosed with dysphagia: a retrospective cohort study.Frontiers in nutrition · 2025Article
- Association between the C-reactive protein/albumin ratio and mortality in older Japanese patients with dysphagia.Frontiers in nutrition · 2024Article
- Does enteral nutrition through a percutaneous endoscopic gastrostomy, attenuate Helicobacter pylori colonization?: is it worth mentioning?Revista da Associacao Medica Brasileira (1992) · 2023Article
- Association between serum albumin and mortality in Japan older people with dysphagia.Scientific reports · 2022Article
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe long-term outcomes of artificial nutrition in older people with dysphagia remain uncertain. Enteral nutrition via percutaneous endoscopic gastrostomy (PEG) is one of the major methods of artificial nutrition. Enteral feeding is indicated for patients with a functional gastrointestinal tract. However, total parenteral nutrition (TPN) is often inappropriately chosen for artificial nutrition in Japan, even in patients with a functional gastrointestinal tract, as PEG has recently been viewed as an unnecessary life-prolonging treatment in Japan. This study aimed to compare the long-term outcomes between PEG and TPN.
methodsThis single-center retrospective cohort study investigated long-term outcomes in older patients with dysphagia who received PEG or TPN between January 2014 and January 2017. The primary outcome was survival time. Secondary outcomes were oral intake recovery, discharge to home, and the incidence of severe pneumonia and sepsis. We performed 1-to-1 propensity score matching using a 0.05 caliper. The Kaplan-Meier method, log-rank test, and Cox regression analysis were used to compare the survival time between groups.
resultsWe identified 253 patients who received PEG (n = 180) or TPN (n = 73). Older patients, those with lower nutritional states, and severe dementia were more likely to receive TPN. Propensity score matching created 55 pairs. Survival time was significantly longer in the PEG group (median, 317 vs 195 days; P = 0.017). The hazard ratio for PEG relative to TPN was 0.60 (95% confidence interval: 0.39-0.92; P = 0.019). There were no significant differences between the groups in oral intake recovery and discharge to home. The incidence of severe pneumonia was significantly higher in the PEG group (50.9% vs 25.5%, P = 0.010), whereas sepsis was significantly higher in the TPN group (10.9% vs 30.9%, P = 0.018).
conclusionsPEG was associated with a significantly longer survival time, a higher incidence of severe pneumonia, and a lower incidence of sepsis compared with TPN.
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