ArticlePLoS biology2019
Symmetry breaking in the embryonic skin triggers directional and sequential plumage patterning.
Article in PLoS biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Color patterns as a model for connecting developmental mechanisms to phenotypic evolution.Nature communications · 2026Review
- Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Organizational principles of integumentary organs: Maximizing variations for effective adaptation.Developmental biology · 2025Review
- Comparative transcriptomics in serial organs uncovers early and pan-organ developmental changes associated with organ-specific morphological adaptation.Nature communications · 2025Article
- From spots to stripes: Evolution of pigmentation patterns in monkeyflowers via modulation of a reaction-diffusion system and its prepatterns.bioRxiv : the preprint server for biology · 2025Article
- Review
- Gap junctions in Turing-type periodic feather pattern formation.PLoS biology · 2024Article
- Periodic pattern formation during embryonic development.Biochemical Society transactions · 2024Review
- Turing Pattern Formation in Reaction-Cross-Diffusion Systems with a Bilayer Geometry.Bulletin of mathematical biology · 2024Article
- Novel Aspects in Pattern Formation Arise from Coupling Turing Reaction-Diffusion and Chemotaxis.Bulletin of mathematical biology · 2023Article
- An active traveling wave of Eda/NF-κB signaling controls the timing and hexagonal pattern of skin appendages in zebrafish.Development (Cambridge, England) · 2023Article
- Rapid mechanosensitive migration and dispersal of newly divided mesenchymal cells aid their recruitment into dermal condensates.PLoS biology · 2023Article
- Bat teeth illuminate the diversification of mammalian tooth classes.Nature communications · 2023Article
- Cell shape anisotropy contributes to self-organized feather pattern fidelity in birds.PLoS biology · 2022Article
- A conserved molecular template underlies color pattern diversity in estrildid finches.Science advances · 2022Article
- Waves in Embryonic Development.Annual review of biophysics · 2022Review
- Systems for intricate patterning of the vertebrate anatomy.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2021Article
- Symmetry breaking of tissue mechanics in wound induced hair follicle regeneration of laboratory and spiny mice.Nature communications · 2021Article
- Review
- Avian Pigment Pattern Formation: Developmental Control of Macro- (Across the Body) and Micro- (Within a Feather) Level of Pigment Patterns.Frontiers in cell and developmental biology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of an organism involves the formation of patterns from initially homogeneous surfaces in a reproducible manner. Simulations of various theoretical models recapitulate final states of natural patterns, yet drawing testable hypotheses from those often remains difficult. Consequently, little is known about pattern-forming events. Here, we surveyed plumage patterns and their emergence in Galliformes, ratites, passerines, and penguins, together representing the three major taxa of the avian phylogeny, and built a unified model that not only reproduces final patterns but also intrinsically generates shared and varying directionality, sequence, and duration of patterning. We used in vivo and ex vivo experiments to test its parameter-based predictions. We showed that directional and sequential pattern progression depends on a species-specific prepattern: an initial break in surface symmetry launches a travelling front of sharply defined, oriented domains with self-organising capacity. This front propagates through the timely transfer of increased cell density mediated by cell proliferation, which controls overall patterning duration. These results show that universal mechanisms combining prepatterning and self-organisation govern the timely emergence of the plumage pattern in birds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.