Observational studyMedicine2019
The risk of herpes zoster virus infection in patients with depression: A longitudinal follow-up study using a national sample cohort.
Observational study in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Bidirectional relationship between human herpes virus reactivation and depression: a systematic review and meta-analysis.Journal of neurovirology · 2025Pooled it
- Risk factors for herpes zoster infections: a systematic review and meta-analysis unveiling common trends and heterogeneity patterns.Infection · 2024Pooled it
- Chondromalacia patella increases the risk of herpes zoster: a population-based study.BMC musculoskeletal disorders · 2022Trial
- Calculus-induced obstructive hydronephrosis and herpes zoster risk: a retrospective analysis of the TriNetX global database.European journal of medical research · 2025Article
- The Risk of Herpes Zoster in Patients with Depressive Disorders: A German Claims Database Analysis.Infectious diseases and therapy · 2025Article
- Exploring the Potential Stimuli and Deterrents of Varicella-Zoster Viral Reactivation: A Scoping Review.Cureus · 2025Review
- No Evidence for a Causal Association Between Depression and Herpes Zoster or Post-Herpetic Neuralgia: A Mendelian Randomization Study.Journal of pain research · 2025Article
- Is There such a Thing as Post-Viral Depression?: Implications for Precision Medicine.Biomolecules & therapeutics · 2024Review
- Prevalence of Paternal Prenatal Depression and Its Associated Factors in Saudi Arabia.Risk management and healthcare policy · 2024Article
- Non-alcoholic fatty liver disease associated with greater herpes zoster risk than alcoholic fatty liver disease.European journal of medical research · 2023Article
- The Impact of Covid-19 Pandemic on Mental Health Services: A Comparison Between First Psychiatric Consultations Before and After the Pandemic.Clinical neuropsychiatry · 2023Article
- Risk of Herpes Zoster in Patients with Pulmonary Tuberculosis-A Population-Based Cohort Study.International journal of environmental research and public health · 2023Article
- Prevalence and healthcare utilization in managing herpes zoster in primary care: a retrospective study in an Asian urban population.Frontiers in public health · 2023Article
- Modeled impact of the COVID-19 pandemic and associated reduction in adult vaccinations on herpes zoster in the United States.Human vaccines & immunotherapeutics · 2022Article
- The Risk of Herpes Zoster in Women with Polycystic Ovary Syndrome: A Retrospective Population-Based Study.International journal of environmental research and public health · 2022Article
- Association between de Quervain syndrome and herpes zoster: a population-based cohort study.BMJ open · 2021Article
- Burden of Herpes Zoster in Adult Patients with Underlying Conditions: Analysis of German Claims Data, 2007-2018.Dermatology and therapy · 2021Article
- Plantar fascial fibromatosis and herpes zoster.PloS one · 2021Article
- To Investigate the Risk of Herpes Zoster in Women With Endometriosis: A Taiwan National Population-Based Cohort Study.Frontiers in medicine · 2021Article
- Herpes zoster in patients with sciatica.BMC musculoskeletal disorders · 2020Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The features of herpes zoster share some commonalities with depression, including decreased cellular immunity, a close correlation with nutritional status, and a higher prevalence in the elderly population. We aimed to assess the association between herpes zoster infection and depression in the Korean population.We performed a longitudinal follow-up study of a nationwide sample cohort derived from the Korean National Health Insurance Service database. Individuals diagnosed with depression between 2002 and 2013 (n = 58,278) as well as matched controls (n = 233,112), with both groups comprising 34.3% male and 65.7% female subjects, were extracted and analyzed for the presence of herpes zoster infection. Depression was diagnosed based on the International Classification of Diseases tenth revision (ICD-10) codes F31-F39, while herpes zoster was diagnosed as ICD-10 B02.The rate of herpes zoster infection was higher in the depressed group (6.8% [3967/58,278]) than in the control group (6.3% [14,689/233,122], P < .001). The adjusted hazard ratio (HR) for herpes zoster infection was 1.09 (95% CI: 1.05-1.13) in the depressed group (P < .001). Subgroup analyses revealed that the adjusted HRs for herpes zoster infection were higher only in women younger than 60 years among participants with depression. These HRs were 1.13 (95% CI: 1.02-1.25; P = .016) in women younger than 40 years and 1.11 (95% CI: 1.04-1.17; P < .001) in women aged 40-59 years.Depression is a predictor of herpes zoster infection in Korean women younger than 60 years.
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