Trial reportPediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2020
Early Enteral Nutrition Is Associated With Improved Clinical Outcomes in Critically Ill Children: A Secondary Analysis of Nutrition Support in the Heart and Lung Failure-Pediatric Insulin Titration Trial.
Trial report in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Comparison of the effects of different models of nutrient supply on nutritional status and clinical outcomes in ICU patients: a systematic review and network meta-analysis.European journal of clinical nutrition · 2026Pooled it
- Impact of Angiotensin Receptor-Neprilysin Inhibition Combined with Enteral Nutritional Therapy on Cardiac Performance and Inflammatory Burden in Hemodialysis-Associated Heart Failure: Clinical and Experimental Evidence.Malawi medical journal : the journal of Medical Association of Malawi · 2026Trial
- Feasibility of Enteral Nutrition in Pediatric Septic Shock at a Tertiary Center in Vietnam.Indian journal of pediatrics · 2026Observational
- Acute gastrointestinal injury severity assessment informs nutritional support and prognostic evaluation in critically ill children: a narrative review.Frontiers in nutrition · 2026Review
- Challenges and strategies in ICU nursing for pediatric patients post-craniopharyngioma surgery: a narrative review.Translational pediatrics · 2025Review
- Enteral feeding in pediatric patients with bronchiolitis requiring non-invasive support via nasal interface.Pediatric research · 2025Article
- Nutrition Provision in Children with Heart Disease on Extracorporeal Membrane Oxygenation (ECMO).Pediatric cardiology · 2025Article
- Late Nutrition and Negative Outcomes in a Brazilian Paediatric Intensive Care Unit: A Retrospective Cohort.Journal of paediatrics and child health · 2025Article
- Early versus delayed enteral nutrition in critically ill children under 12 years of age: A systematic review and meta-analysis of randomised controlled trials.Clinical nutrition open science · 2025Article
- The Utilization of Point of Care Ultrasound (POCUS) for the Confirmation of Gastric and Post-Pyloric Feeding Tube Placement in a Pediatric Intensive Care Unit.POCUS journal · 2025Article
- Personalized Nutrition in the Pediatric ICU: Steering the Shift from Acute Stress to Metabolic Recovery and Rehabilitation.Nutrients · 2024Review
- An In-Depth Look at Nutrition Support and Adequacy for Critically Ill Children with Organ Dysfunction.Children (Basel, Switzerland) · 2024Article
- Impact of Early Enteral Nutrition on the Hospital Stay of Pediatric Patients Undergoing Mechanical Ventilation.Journal of pediatric intensive care · 2024Article
- Validation of Indirect Calorimetry in Children Undergoing Single-Limb Non-Invasive Ventilation: A Proof of Concept, Cross-Over Study.Nutrients · 2024Article
- Nutritional and clinical factors associated with acute kidney injury development in critically ill children.Journal of nephrology · 2023Article
- Examining the impact of early enteral nutritional support on postoperative recovery in patients undergoing surgical treatment for gastrointestinal neoplasms.World journal of gastrointestinal surgery · 2023Article
- Association of enteral feeds in critically ill bronchiolitis patients supported by high-flow nasal cannula with adverse events and outcomes.European journal of pediatrics · 2023Article
- Early oral nutritional supplement improves COVID-19 outcomes among hospitalized older patients during the Omicron wave.Nutrition (Burbank, Los Angeles County, Calif.) · 2023Article
- Nutritional status efficacy of early nutritional support in gastrointestinal care: A systematic review and meta-analysis.World journal of gastrointestinal surgery · 2023Article
- Enteral Feeding for Children on Bilevel Positive Pressure Ventilation for Status Asthmaticus.Journal of pediatric intensive care · 2023Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesThe impact of early enteral nutrition on clinical outcomes in critically ill children has not been adequately described. We hypothesized that early enteral nutrition is associated with improved clinical outcomes in critically ill children.
designSecondary analysis of the Heart and Lung Failure-Pediatric Insulin Titration randomized controlled trial.
settingThirty-five PICUs. PATIENTS: Critically ill children with hyperglycemia requiring inotropic support and/or invasive mechanical ventilation who were enrolled for at least 48 hours with complete nutrition data.
interventionsSubjects received nutrition via guidelines that emphasized enteral nutrition and were classified into early enteral nutrition (enteral nutrition within 48 hr of study randomization) and no early enteral nutrition (enteral nutrition after 48 hr of study randomization, or no enteral nutrition at any time). MEASUREMENTS AND MAIN
resultsOf 608 eligible subjects, 331 (54%) received early enteral nutrition. Both early enteral nutrition and no early enteral nutrition groups had similar daily caloric intake over the first 8 study days (median, 36 vs 36 kcal/kg/d; p = 0.93). After controlling for age, body mass index z scores, primary reason for ICU admission, severity of illness, and mean Vasopressor-Inotrope Score at the time of randomization, and adjusting for site, early enteral nutrition was associated with lower 90-day hospital mortality (8% vs 17%; p = 0.007), more ICU-free days (median, 20 vs 17 d; p = 0.02), more hospital-free days (median, 8 vs 0 d; p = 0.003), more ventilator-free days (median, 21 vs 19 d; p = 0.003), and less organ dysfunction (median maximum Pediatric Logistic Organ Dysfunction, 11 vs 12; p < 0.001).
conclusionsIn critically ill children with hyperglycemia requiring inotropic support and/or mechanical ventilation, early enteral nutrition was independently associated with better clinical outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.