Evidence map›Paper›PMID 31577285›Full record

ArticleBiomaterials science2019

A bioactivatable self-quenched nanogel for targeted photodynamic therapy.

Huacheng He, Anna-Liisa Nieminen, Peisheng Xu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Huacheng HeDepartment of Drug Discovery and Biomedical Sciences, University of South Carolina, 715 Sumter St., Columbia, SC 29208, USA. xup@cop.sc.edu.
Anna-Liisa NieminenDepartment of Drug Discovery and Biomedical Sciences, College of Pharmacy, Medical University of South Carolina, 70 President Street, MSC 140, Charleston, SC 29425, USA.
Peisheng XuDepartment of Drug Discovery and Biomedical Sciences, University of South Carolina, 715 Sumter St., Columbia, SC 29208, USA. xup@cop.sc.edu.ORCID http://orcid.org/0000-0002-4486-7058
University of South Carolina · USMedical University of South Carolina · US

Funding

Brain targeted nanoparticle for Alzheimer's disease therapyR01AG054839 · NIA · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI XU, PEISHENG · 2017 to 2021
$1.8M
Nano-cocktail overcomes multidrug-resistance for ovarian cancer therapyR15CA188847 · NCI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI XU, PEISHENG · 2015 to 2015
$366k
NCI NIH HHS R15 CA188847NIA NIH HHS R01 AG054839
6 · The paper itself

Abstract

Photodynamic therapy has attracted significant attention due to its localized treatment advantage. However, the non-specific distribution of photosensitizers and the subsequent potential toxicity caused by sunshine exposure hinder its wide adoption in cancer treatment. To minimize these unwanted effects and improve its efficacy, we developed a bioactivatable self-quenched nanogel, which remains in its inactive state in healthy tissues. Anti-EGFR Affibody decorated nanogels can effectively target head and neck cancer and release activated pheophorbide A in a reducing environment, such as in the tumor stroma and cytoplasm. Consequently, the EGFR targeted nanogel coupled with NIR irradiation alleviates tumor burden by 94.5% while not inducing systemic toxicity.

Indexed as

AnimalsCell Line, TumorCell ProliferationCell SurvivalChlorophyllErbB ReceptorsHead and Neck NeoplasmsHeLa CellsHumansLigandsMiceMolecular Targeted TherapyNanogelsPhotochemotherapyRadiation-Sensitizing AgentsSquamous Cell Carcinoma of Head and NeckChlorophyllEGFR protein, humanErbB ReceptorsLigandsNanogelspheophorbide aRadiation-Sensitizing Agents

Identifiers

PMID31577285
PMCPMC6864251
OpenAlexW2974614798

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.