ArticleBrain and behavior2019
Dentate gyrus neurons that are born at the peak of development, but not before or after, die in adulthood.
Article in Brain and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- The Dentate Gyrus Grows Throughout Life Despite Turnover of Developmentally-Born Neurons.Hippocampus · 2026Article
- Electroconvulsive Shock Induces Greater Plasticity of Dentate Gyrus Neurons Born in Adulthood Than Those Born in Development.The European journal of neuroscience · 2026Article
- A mouse model of early sporadic tau pathology induces neurogenic plasticity in the hippocampus.PloS one · 2025Article
- Repeated Ketamine Anesthesia during the Neonatal Period Impairs Hippocampal Neurogenesis and Long-Term Neurocognitive Function by Inhibiting Mfn2-Mediated Mitochondrial Fusion in Neural Stem Cells.Molecular neurobiology · 2024Article
- Genetic labeling of embryonically-born dentate granule neurons in young mice using the PenkScientific reports · 2024Article
- Hepcidin deficiency impairs hippocampal neurogenesis and mediates brain atrophy and memory decline in mice.Journal of neuroinflammation · 2024Article
- Abnormal chromatin remodeling caused by ARID1A deletion leads to malformation of the dentate gyrus.Cell death and differentiation · 2023Article
- Article
- Adult-born neurons add flexibility to hippocampal memories.Frontiers in neuroscience · 2023Review
- Adult neurogenesis acts as a neural regularizer.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- KProceedings of the National Academy of Sciences of the United States of America · 2022Article
- The temporal origin of dentate granule neurons dictates their role in spatial memory.Molecular psychiatry · 2021Article
- Hippocampal neurogenesis promotes preference for future rewards.Molecular psychiatry · 2021Article
- Kv1.1 channels regulate early postnatal neurogenesis in mouse hippocampus via the TrkB signaling pathway.eLife · 2021Article
- The environmental sculpting hypothesis of juvenile and adult hippocampal neurogenesis.Progress in neurobiology · 2021Article
- Prolonged development of long-term potentiation at lateral entorhinal cortex synapses onto adult-born neurons.PloS one · 2021Article
- Ontogeny of adult neural stem cells in the mammalian brain.Current topics in developmental biology · 2021Review
- The neurotoxic effect of isoflurane on age-defined neurons generated from tertiary dentate matrix in mice.Brain and behavior · 2021Article
- Adult-Born Hippocampal Neurons Undergo Extended Development and Are Morphologically Distinct from Neonatally-Born Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Therapeutic Plasticity of Neural Stem Cells.Frontiers in neurology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
introductionIn the dentate gyrus of the rodent hippocampus, neurogenesis begins prenatally and continues to the end of life. Adult-born neurons often die in the first few weeks after mitosis, but those that survive to 1 month persist indefinitely. In contrast, neurons born at the peak of development are initially stable but can die later in adulthood. Physiological and pathological changes in the hippocampus may therefore result from both the addition of new neurons and the loss of older neurons. The extent of neuronal loss remains unclear since no studies have examined whether neurons born at other stages of development also undergo delayed cell death.
methodsWe used BrdU to label dentate granule cells that were born in male rats on embryonic day 19 (E19; before the developmental peak), postnatal day 6 (P6; peak), and P21 (after the peak). We quantified BrdU
resultsConsistent with previous work, there was a 15% loss of P6-born neurons between 2 and 6 months of age. In contrast, E19- or P21-born neurons were stable throughout young adulthood. DISCUSSION: Delayed death of P6-born neurons suggests these cells may play a unique role in hippocampal plasticity adulthood, for example, by contributing to the turnover of hippocampal memory. Their loss may also play a role in disorders that are characterized by hippocampal atrophy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.