Evidence map›Paper›PMID 31576504›Full record

ArticleAnnals of biomedical engineering2020

Triple Contrast CT Method Enables Simultaneous Evaluation of Articular Cartilage Composition and Segmentation.

Miitu K M Honkanen, Annina E A Saukko, Mikael J Turunen, Wujun Xu, Goran Lovric, Juuso T J Honkanen, Mark W Grinstaff, Vesa-Pekka Lehto, Juha Töyräs

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Miitu K M HonkanenDepartment of Applied Physics, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland. miitu.honkanen@uef.fi.ORCID http://orcid.org/0000-0002-2548-4457
Annina E A SaukkoDepartment of Applied Physics, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.ORCID http://orcid.org/0000-0001-8678-4675
Mikael J TurunenDepartment of Applied Physics, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.ORCID http://orcid.org/0000-0003-1093-1178
Wujun XuDepartment of Applied Physics, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.ORCID http://orcid.org/0000-0002-3177-4709
Goran LovricCentre d'Imagerie BioMédicale, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-0833-4043
Juuso T J HonkanenCenter of Oncology, Kuopio University Hospital, Kuopio, Finland.ORCID http://orcid.org/0000-0002-9150-9253
Mark W GrinstaffDepartments of Biomedical Engineering, Chemistry, and Medicine, Boston University, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5453-3668
Vesa-Pekka LehtoDepartment of Applied Physics, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.ORCID http://orcid.org/0000-0001-8153-1070
Juha TöyräsDepartment of Applied Physics, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.ORCID http://orcid.org/0000-0002-8035-1606
University of Eastern Finland · FIBoston University · USKuopio University Hospital · FIPaul Scherrer Institute · CHQueensland University of Technology · AU

Funding

Academy of Finland 307932The Research Committee of the Kuopio University Hospital Catchment Area for the State Research Funding 5041769The Research Committee of the Kuopio University Hospital Catchment Area for the State Research Funding 5654199
6 · The paper itself

Abstract

Early degenerative changes of articular cartilage are detected using contrast-enhanced computed tomography (CT) with a cationic contrast agent (CA). However, cationic CA diffusion into degenerated cartilage decreases with proteoglycan depletion and increases with elevated water content, thus hampering tissue evaluation at early diffusion time points. Furthermore, the contrast at synovial fluid-cartilage interface diminishes as a function of diffusion time hindering accurate cartilage segmentation. For the first time, we employ quantitative dual-energy CT (QDECT) imaging utilizing a mixture of three CAs (cationic CA4+ and non-ionic gadoteridol which are sensitive to proteoglycan and water contents, respectively, and bismuth nanoparticles which highlight the cartilage surface) to simultaneously segment the articulating surfaces and determine of the cartilage condition. Intact healthy, proteoglycan-depleted, and mechanically injured bovine cartilage samples (n = 27) were halved and imaged with synchrotron microCT 2-h post immersion in triple CA or in dual CA (CA4+ and gadoteridol). CA4+ and gadoteridol partitions were determined using QDECT, and pairwise evaluation of these partitions was conducted for samples immersed in dual and triple CAs. In conclusion, the triple CA method is sensitive to proteoglycan depletion while maintaining sufficient contrast at the articular surface to enable detection of cartilage lesions caused by mechanical impact.

Indexed as

X-Ray MicrotomographyAnimalsCartilage, ArticularCattleContrast MediaPatellaContrast MediaComputed tomographyContrast-enhanced computed tomographyDual contrast agentPost-traumatic osteoarthritisSynchrotron microCTTriple contrast agent

Identifiers

PMID31576504
PMCPMC6949199
OpenAlexW2977495963

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.