ArticleClinical rheumatology2020
Infectious profile in inpatients with ANCA-associated vasculitis: a single-center retrospective study from Southern China.
Article in Clinical rheumatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
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Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Pooled it
- Pooled it
- Insights into the paradoxical effect of smoking on vasculitis: a comprehensive review.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2024Article
- Prevalence and characteristics of bronchiectasis in ANCA-associated vasculitis: A systematic review and meta-analysis.Archives of rheumatology · 2024Review
- T lymphocyte subsets and immunoglobulin and complement levels are associated with the infection status of patients with antineutrophil cytoplasmic antibody-associated vasculitis.Clinical and experimental medicine · 2023Article
- Clinical features and markers to identify pulmonary lesions caused by infection or vasculitis in AAV patients.BMC pulmonary medicine · 2023Article
- Severe infections in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis: a retrospective cohort study with a clinical phenotype approach.Rheumatology international · 2020Observational
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectivesInfection is a common complication in ANCA-associated vasculitis (AAV). The study goal was to investigate the infectious profile in patients with AAV from Southern China.
methodsA retrospective study was performed on the inpatients from the First Affiliated Hospital of Sun Yat-sen University from 2012 to 2017. Demographic and clinical characteristics were recorded.
resultsA total of 132 AAV inpatients with 174 episodes of infection (prevalence, 63.8%) were included. Lung was the most commonly involved. Ninety-six (72.7%) patients developed infection during the first 6 months after AAV diagnosis. Bacteria (75.9%) were the prominent microbes. Gram-negative bacteria were predominant (71.4%). The most frequently isolated bacteria were P. aeruginosa (16.7%) and A. baumannii (16.7%). Mixed infection accounted for 14.9% of the episodes, while fungal infection accounted for 6.3%. Mortality rate was 12.9% (17/132). Six deceased patients (46.2%) were infected with multiple pathogens. In multivariate analysis, smoking (odds ratio (OR) 2.38, 95% confidence interval (CI) 1.13-5.03, P = 0.02), kidney involvement (OR 2.56, 95% CI 1.11-5.88, P = 0.03), lymphopenia (OR 2.33, 95% CI 1.20-4.55, P = 0.01), and dialysis (OR 3.06, 95% CI 1.14-8.20, P = 0.03) were associated with infection in patients with AAV.
conclusionsBacteria, especially Gram-negative bacteria, were the major pathogens in Chinese AAV patients. Mixed infection was a great threat to death. Infection tended to develop within the 6 months after AAV diagnosis. Smoking, kidney involvement, dialysis, and lymphopenia increased the risk of infection in patients with AAV.Key Points• Infection tended to develop within the 6 months after AAV diagnosis.• Gram-negative bacteria were the leading pathogens.• Smoking, kidney involvement, dialysis, and lymphopenia increased the risk of infection in patients with AAV.
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