Evidence map›Paper›PMID 31576422›Full record

ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2020

Resuscitative endovascular balloon occlusion of the aorta (REBOA) in a swine model of hemorrhagic shock and blunt thoracic injury.

Carl A Beyer, Guillaume L Hoareau, Harris W Kashtan, Andrew M Wishy, Connor Caples, Marguerite Spruce, John K Grayson, Lucas P Neff, Timothy K Williams, Michael A Johnson

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Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Carl A BeyerClinical Investigation Facility, David Grant USAF Medical Center, Travis Air Force Base, Fairfield, CA, USA. cbeyer@ucdavis.edu.ORCID http://orcid.org/0000-0002-9785-8526
Guillaume L HoareauClinical Investigation Facility, David Grant USAF Medical Center, Travis Air Force Base, Fairfield, CA, USA.
Harris W KashtanClinical Investigation Facility, David Grant USAF Medical Center, Travis Air Force Base, Fairfield, CA, USA.
Andrew M WishyClinical Investigation Facility, David Grant USAF Medical Center, Travis Air Force Base, Fairfield, CA, USA.
Connor CaplesClinical Investigation Facility, David Grant USAF Medical Center, Travis Air Force Base, Fairfield, CA, USA.
Marguerite SpruceClinical Investigation Facility, David Grant USAF Medical Center, Travis Air Force Base, Fairfield, CA, USA.
John K GraysonClinical Investigation Facility, David Grant USAF Medical Center, Travis Air Force Base, Fairfield, CA, USA.
Lucas P NeffDepartment of Surgery, Wake Forest Baptist Medical Center, Winston-Salem, NC, USA.
Timothy K WilliamsDepartment of Surgery, Wake Forest Baptist Medical Center, Winston-Salem, NC, USA.
Michael A JohnsonClinical Investigation Facility, David Grant USAF Medical Center, Travis Air Force Base, Fairfield, CA, USA.
David Grant USAF Medical Center · USAtrium Health Wake Forest Baptist · US

Funding

Defense Health Agency W81XWH-16-2-0043
6 · The paper itself

Abstract

purposeWhile resuscitative endovascular balloon occlusion of the aorta (REBOA) is contraindicated in patients with aortic injuries, this technique may benefit poly-trauma patients with less extreme thoracic injuries. The purpose of this study was to characterize the effects of thoracic injury on hemodynamics during REBOA and the changes in pulmonary contusion over time in a swine model.

methodsTwelve swine were anesthetized, instrumented, and randomized to receive either a thoracic injury with 5 impacts to the chest or no injury. All animals underwent controlled hemorrhage of 25% blood volume followed by 45 min of Zone 1 REBOA. Animals were then resuscitated with shed blood, observed during a critical care period, and euthanized after 6 h of total experimental time.

resultsThere were no differences between the groups at baseline. The only difference after 6 h was a lower hemoglobin in the thoracic trauma group (8.4 ± 0.8 versus 9.4 ± 0.6 g/dL, P = 0.04). The average proximal mean arterial pressures were significantly lower in the thoracic trauma group during aortic occlusion [103 (98-108) versus 117 (115-124) mmHg, P = 0.04]. There were no differences between the pulmonary contusion before REBOA and at the end of the experiment in size (402 ± 263 versus 356 ± 291 mL, P = 0.782) or density (- 406 ± 127 versus - 299 ± 175 HFU, P = 0.256).

conclusionsThoracic trauma blunted the proximal arterial pressure augmentation during REBOA but had minimal impacts on resuscitative outcomes. This initial study indicates that REBOA does not seem to exacerbate pulmonary contusion in swine, but blunt thoracic injuries may attenuate the expected rises in proximal blood pressure during REBOA.

Indexed as

Balloon OcclusionEndovascular ProceduresShock, HemorrhagicThoracic InjuriesAnimalsDisease Models, AnimalHemodynamicsResuscitationSwineBlunt thoracic traumaHemorrhagic shockPoly-traumaPulmonary contusionResuscitative endovascular balloon occlusion of the aorta (REBOA)

Identifiers

PMID31576422
OpenAlexW2977813947

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.