ArticleIUCrJ2019
Automated serial rotation electron diffraction combined with cluster analysis: an efficient multi-crystal workflow for structure determination.
Article in IUCrJ, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 96 citations in OpenAlex.
- Practical crystallography with a transmission electron microscope.Journal of microscopy · 2026Article
- Automated serial electron diffraction: implementation inJournal of applied crystallography · 2026Article
- Sub-Ångström Three-Dimensional Electron Diffraction Reveals Crystal Structures and Phase Transformations in Liquids.Journal of the American Chemical Society · 2026Article
- Multi-Crystal X-Ray Diffraction (MCXRD) Bridges the Crystallographic Characterisation Gap in Chemistry and Materials Science: Application to MOFs.Angewandte Chemie (International ed. in English) · 2026Article
- Article
- Automated and real-time structure solution using 3D electron diffraction.Journal of applied crystallography · 2025Article
- Serial Chemical Crystallography for Autonomous Quantitative Phase Analysis in an Electron Microscope.Small methods · 2025Article
- Quantification of enantiomorphs in chiral crystalline powders through three-dimensional electron diffraction.Nature chemistry · 2025Article
- Synthesis of three-dimensional covalent organic frameworks through a symmetry reduction strategy.Nature chemistry · 2025Article
- Reaching the potential of electron diffraction.Cell reports. Physical science · 2024Article
- Applying 3D ED/MicroED workflows toward the next frontiers.Acta crystallographica. Section C, Structural chemistry · 2024Article
- Compositional Analysis of Complex Mixtures using Automatic MicroED Data Collection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- High-Throughput Identification of Crystalline Natural Products from Crude Extracts Enabled by Microarray Technology and microED.ACS central science · 2024Article
- Article
- Electron crystallography and dedicated electron-diffraction instrumentation.Acta crystallographica. Section E, Crystallographic communications · 2023Article
- Serial rotation electron diffraction for rapid phase analysis to accelerate materials development.Nature chemistry · 2023Article
- High-throughput phase elucidation of polycrystalline materials using serial rotation electron diffraction.Nature chemistry · 2023Article
- Improving data quality for three-dimensional electron diffraction by a post-column energy filter and a new crystal tracking method.Journal of applied crystallography · 2022Article
- Article
- Single-crystal structure determination of nanosized metal-organic frameworks by three-dimensional electron diffraction.Nature protocols · 2022Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serial rotation electron diffraction (SerialRED) has been developed as a fully automated technique for three-dimensional electron diffraction data collection that can run autonomously without human intervention. It builds on the previously established serial electron diffraction technique, in which submicrometre-sized crystals are detected using image processing algorithms. Continuous rotation electron diffraction (cRED) data are collected on each crystal while dynamically tracking the movement of the crystal during rotation using defocused diffraction patterns and applying a set of deflector changes. A typical data collection screens up to 500 crystals per hour, and cRED data are collected from suitable crystals. A data processing pipeline is developed to process the SerialRED data sets. Hierarchical cluster analysis is implemented to group and identify the different phases present in the sample and to find the best matching data sets to be merged for subsequent structure analysis. This method has been successfully applied to a series of zeolites and a beam-sensitive metal-organic framework sample to study its capability for structure determination and refinement. Two multi-phase samples were tested to show that the individual crystal phases can be identified and their structures determined. The results show that refined structures obtained using automatically collected SerialRED data are indistinguishable from those collected manually using the cRED technique. At the same time, SerialRED has lower requirements of expertise in transmission electron microscopy and is less labor intensive, making it a promising high-throughput crystal screening and structure analysis tool.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.