ArticleClinical epidemiology2019
Impact of the Charlson Comorbidity Index score on risk prediction by single-photon emission computed tomography myocardial perfusion imaging following myocardial infarction.
Article in Clinical epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 12 citations in OpenAlex.
- Primary Biliary Cholangitis Increases Mortality Irrespective of Presence or Absence of Cirrhosis.Liver international : official journal of the International Association for the Study of the Liver · 2026Article
- Associations of the Charlson comorbidity index with depression and mortality among the U.S. adults.Frontiers in public health · 2024Article
- Ejection fraction at hospital admission stratifies mortality risk in HFmrEF patients aged ≥ 70 years: a retrospective analysis from a tertiary university institution.Aging clinical and experimental research · 2023Article
- Comparison of Home-Based vs Center-Based Cardiac Rehabilitation in Hospitalization, Medication Adherence, and Risk Factor Control Among Patients With Cardiovascular Disease.JAMA network open · 2022Article
- The Effects of Metal Exposures on Charlson Comorbidity Index Using Zero-Inflated Negative Binomial Regression Model: NHANES 2011-2016.Biological trace element research · 2021Article
- Subsequent Development of Epithelial Ovarian Cancer After Ovarian Surgery for Benign Ovarian Tumor: A Population-Based Cohort Study.Clinical epidemiology · 2020Article
- Niacin, lutein and zeaxanthin and physical activity have an impact on Charlson comorbidity index using zero-inflated negative binomial regression model: National Health and Nutrition Examination Survey 2013-2014.BMC public health · 2019Article
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6 authors at 3 institutions in 1 country.
Funding
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Abstract
backgroundComorbidity is common among patients with myocardial infarction (MI). We examined whether comorbidity level modified the single-photon emission computed tomography myocardial perfusion imaging (SPECT MPI)-based prediction of 5-year risk of MI and all-cause death in patients with MI.
methodsThis cohort study included patients with prior MI having a SPECT MPI at Aarhus University Hospital, Denmark, 1999-2011. Using nationwide registries, we obtained information on comorbidity levels (low, moderate, and severe) and outcomes. We computed risk and hazard ratios (HRs) with 95% confidence intervals (CIs) for MI and all-cause death, comparing normal (no defects) versus abnormal scan (reversible and/or fixed defects) using Cox regression adjusting for sex, age, and comorbidity level.
resultsWe identified 1,192 patients with MI before SPECT MPI. The 5-year risk for patients with normal versus abnormal scans were 11.7% versus 18.3% for MI, and 8.0% versus 13.2% for all-cause death, respectively. The overall 5-year adjusted HR (aHR) of MI was 1.56 (95% CI: 1.09-2.21), 1.33 (95% CI: 0.82-2.15) with low comorbidity, 1.39 (95% CI: 0.68-2.83) with moderate comorbidity, and 2.53 (95% CI: 1.14-5.62) with severe comorbidity. Similarly, the 5-year aHR for all-cause death was 1.39 (95% CI: 0.90-2.14) overall; 2.33 (95% CI: 0.79-6.84) with low comorbidity, 2.05 (95% CI: 0.69-6.06) with moderate comorbidity, and 1.07 (95% CI: 0.64-1.80) with severe comorbidity.
conclusionWe conclude that comorbidity level may modify the 5-year risk prediction associated with an abnormal SPECT MPI scan in patients with previous MI.
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