ArticleJournal of human reproductive sciences
Comparison of Clinical, Metabolic, Hormonal, and Ultrasound Parameters among the Clomiphene Citrate-Resistant and Clomiphene Citrate-Sensitive Polycystic Ovary Syndrome Women.
Article in Journal of human reproductive sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- How to Choose the Optimal Starting Dose of Clomiphene Citrate (50 or 100 mg per Day) for a First Cycle of Ovulation Induction in Anovulatory PCOS Women?Journal of clinical medicine · 2023Article
- Secretory products of the corpus luteum and preeclampsia.Human reproduction update · 2021Review
- Identification of predictors of the ovarian response to clomiphene citrate in infertile women with polycystic ovary syndrome: a prospective cohort study.The Journal of international medical research · 2021Article
- Metformin effects on zonulin level in polycystic ovarian women.ADMET & DMPK · 2021Article
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Authors and funding
5 authors.
Funding
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Abstract
objectiveThe objective of the study is to compare the clinical, metabolic, hormonal, and ultrasound parameters among the clomiphene citrate (CC)-sensitive and CC-resistant polycystic ovary syndrome (PCOS) women. MATERIALS AND
methodsThis was a prospective observational study.
settingThe study was conducted at the infertility outpatient department in a government hospital. SAMPLE SIZE: A total of 164 women with PCOS-related infertility were included.
interventionIncremental dose of CC from 50 mg/day to 100 mg/day to 150 mg/day over three cycles was given. RESPONSE: Ovulation was the outcome. Those who failed to ovulate with 150 mg CC were CC resistant.
resultsOf the total 164 PCOS women, 88 (53.7%) were CC resistant and 76 (46.3%) were CC sensitive. Of the 76 PCOS women who ovulated, maximum, i.e., 37 (22.6%) women ovulated with 100 mg CC. The most common diagnostic feature of PCOS in this study was hyperandrogenism (96.3%). CC-resistant PCOS women had significantly higher weight, waist circumference, waist-hip ratio, and body mass index (BMI). Significantly longer menstrual cycles and hyperandrogenism were significantly more common in CC-resistant group. CC-resistant group had a significantly higher ovarian reserve (ovarian volume, antral follicle count, and anti-Müllerian hormone values). Baseline luteinizing hormone (LH) values and LH-follicle stimulating hormone ratio were significantly higher in the CC-resistant group.
conclusionClomiphene-resistant PCOS women have significantly higher hyperandrogenism, longer cycles, more deranged metabolic profile, higher BMI, and ovarian reserve. These differences should be kept in mind while deciding the ovulation induction protocol.
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