Evidence map›Paper›PMID 31575999›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2020

Evaluation of clinically asymptomatic high risk infants with congenital cytomegalovirus infection.

Andrea Ronchi, Fiker Zeray, Lizette E Lee, Kris E Owen, Angela G Shoup, Fabiana Garcia, Liliana N Vazquez, Joseph B Cantey, Shawn Varghese, Lorenza Pugni and 2 more

Open access · bronzeAbstract readMulticenter Study
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Maternal-Fetal Infections (Cytomegalovirus,Pathogens (Basel, Switzerland) · 2022
    Article
  11. An Overview of Cytomegalovirus Infection in Pregnancy.Diagnostics (Basel, Switzerland) · 2022
    Review
  12. Review
  13. Observational
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Andrea RonchiDepartments of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Fiker ZerayChildren's Medical Center, Dallas, TX, USA.
Lizette E LeeDepartments of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Kris E OwenChildren's Medical Center, Dallas, TX, USA.
Angela G ShoupChildren's Medical Center, Dallas, TX, USA.
Fabiana GarciaFundación del Centro de Estudios Infectológicos, Buenos Aires, Argentina.
Liliana N VazquezFundación del Centro de Estudios Infectológicos, Buenos Aires, Argentina.
Joseph B CanteyDepartments of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Shawn VargheseDepartments of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Lorenza PugniNeonatal Intensive Care Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milano, Italy.
Fabio MoscaNeonatal Intensive Care Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milano, Italy.
Pablo J SánchezDepartments of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA. Pablo.Sanchez@nationwidechildrens.org.
Children's Medical Center · USThe University of Texas Southwestern Medical Center · USFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITFundación Centro de Estudios Infectológicos · ARParkland Health & Hospital System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the frequency of abnormal findings on evaluation of neonates with congenital CMV infection who have a normal physical examination STUDY

designRetrospective, 2-center study (1996-2017) that reviewed results of complete blood cell count and platelets, serum alanine aminotransferase (ALT) and bilirubin concentrations, eye examination, cranial ultrasonography or other neuroimaging, and brainstem evoked responses performed on neonates with congenital CMV infection and a normal physical examination

resultsOf 34 infants with congenital CMV infection and a normal physical examination, 56% (19/34) had ≥1 abnormality: 39%, elevated ALT concentration; 45%, abnormal neuroimaging (five, lenticulostriate vasculopathy; six, intraventricular hemorrhage; four, calcifications); 12%, anemia; 16%, thrombocytopenia; and 3%, chorioretinitis. Seven (21%) infants had sensorineural hearing loss, and 18 infants received antiviral therapy.

conclusionSome infants with congenital CMV infection and a normal physical examination had abnormalities on laboratory or neuroimaging evaluation, which in some cases prompted antiviral treatment.

Indexed as

Physical ExaminationAlanine TransaminaseAntiviral AgentsBlood Cell CountBrainCytomegalovirus InfectionsFemaleGanciclovirGestational AgeHearing Loss, SensorineuralHumansInfant, NewbornMaleNeuroimagingRetrospective StudiesThrombocytopeniaAlanine TransaminaseAntiviral AgentsGanciclovirValganciclovir

Identifiers

PMID31575999
PMCPMC7223780
OpenAlexW2979229333

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.