ArticleScientific reports2019
Prediction of pathological fracture in patients with metastatic disease of the lower limb.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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10 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
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- Practice and principles of stereotactic body radiation therapy for spine and non-spine bone metastases.Clinical and translational radiation oncology · 2024Article
- Mirels' score for upper limb metastatic lesions: do we need a different cutoff for recommending prophylactic fixation?JSES international · 2022Article
- Short-term effects of COVID-19 on the risk of traumatic fractures in China cities.Scientific reports · 2022Article
- Fracture risk assessment in children with benign bone lesions of long bones.World journal of clinical cases · 2021Article
- Fracture Risk of Long Bone Metastases: A Review of Current and New Decision-Making Tools for Prophylactic Surgery.Cancers · 2021Review
- Current concepts in the surgical treatment of skeletal metastases.World journal of orthopedics · 2020Review
- Fracture risk assessment and clinical decision making for patients with metastatic bone disease.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Review
- CORR Insights®: Is Delayed Time to Surgery Associated with Increased Short-term Complications in Patients with Pathologic Hip Fractures?Clinical orthopaedics and related research · 2020Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate if the risk of pathological fracture can be predicted with the proportion of body weight that can be put through the affected leg in patients with metastatic bone disease of the lower limb. A prospective observational study was conducted in patients with metastatic disease in the lower limb. Receiver Operator Characteristic curves were used to identify the optimum threshold level of single stance weight bearing to predict fracture and compared to the Mirels score. Patients who underwent surgery could weight bear significantly less than those who did not have surgical intervention. The optimum threshold to predict pathological fracture was 85% of total body weight. No patient below the threshold level of 85% single stance body weight sustained a pathological fracture. The use of single stance body weight can be a useful in conjunction with the Mirels score to predict pathological fracture. If less than 85% of total body weight can be put through the affected limb, the risk of fracture increases, and consideration of treatment is suggested.
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