ArticleScientific reports2019
A novel multi-parametric analysis of non-invasive methods to assess animal distress during chronic pancreatitis.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Grimace scale, burrowing, and nest building for the assessment of post-surgical pain in mice and rats-A systematic review.Frontiers in veterinary science · 2022Pooled it
- The Predictive Accuracy of Methods Commonly Used for Evaluating Animal Distress.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Article
- Evidence-Based Severity Assessment of Animal Models for Pancreatic Cancer.Biomedicines · 2024Article
- Article
- Robustness of a multivariate composite score when evaluating distress of animal models for gastrointestinal diseases.Scientific reports · 2023Article
- Article
- Generalizability, Robustness and Replicability When Evaluating Wellbeing of Laboratory Mice with Various Methods.Animals : an open access journal from MDPI · 2022Article
- The neurobiology of pain and facial movements in rodents: Clinical applications and current research.Frontiers in veterinary science · 2022Review
- RELSA-A multidimensional procedure for the comparative assessment of well-being and the quantitative determination of severity in experimental procedures.Frontiers in veterinary science · 2022Article
- Analysis of Pain and Analgesia Protocols in Acute Cerulein-Induced Pancreatitis in Male C57BL/6 Mice.Frontiers in physiology · 2021Article
- Analysis of Animal Well-Being When Supplementing Drinking Water with Tramadol or Metamizole during Chronic Pancreatitis.Animals : an open access journal from MDPI · 2020Article
- The impact of handling technique and handling frequency on laboratory mouse welfare is sex-specific.Scientific reports · 2020Article
- MicroRNAs as systemic biomarkers to assess distress in animal models for gastrointestinal diseases.Scientific reports · 2020Article
- Monitoring of Heart Rate and Activity Using Telemetry Allows Grading of Experimental Procedures Used in Neuroscientific Rat Models.Frontiers in neuroscience · 2020Article
- Social isolation in rats: Effects on animal welfare and molecular markers for neuroplasticity.PloS one · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ethical responsibility, legal requirements and the need to improve the quality of research create a growing interest in the welfare of laboratory animals. Judging the welfare of animals requires readout parameters, which are valid and sensitive as well as specific to assess distress after different interventions. In the present study, we evaluated the sensitivity and specificity of different non-invasive parameters (body weight change, faecal corticosterone metabolites concentration, burrowing and nesting activity) by receiver operating characteristic curves and judged the merit of a multi-parametric analysis by logistic regression. Chronic pancreatitis as well as laparotomy caused significant changes in all parameters. However, the accuracy of these parameters was different between the two animal models. In both animal models, the multi-parametric analysis relying on all the readout parameters had the highest accuracy when predicting distress. This multi-parametric analysis revealed that C57BL/6 mice during the course of chronic pancreatitis often experienced less distress than mice after laparotomy. Interestingly these data also suggest that distress does not steadily increase during chronic pancreatitis. In conclusion, combining these non-invasive methods for severity assessment represents a reliable approach to evaluate animal distress in models such as chronic pancreatitis.
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