Evidence map›Paper›PMID 31575961›Full record

ArticleScientific reports2019

A family of orthologous proteins from centipede venoms inhibit the hKir6.2 channel.

Yajamana Ramu, Zhe Lu

Abstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Inhibition Mechanism of Pancreatic KResearch (Washington, D.C.) · 2026
    Article
  2. Review
  3. Bioactive Peptides and Proteins from Centipede Venoms.Molecules (Basel, Switzerland) · 2022
    Review
  4. Centipede Venom: A Potential Source of Ion Channel Modulators.International journal of molecular sciences · 2022
    Review
  5. Article
  6. Peptide Toxins Targeting KV Channels.Handbook of experimental pharmacology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yajamana RamuDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Zhe LuDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. zhelu@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0001-7108-9303

Funding

Development of novel means to stimulate Ca2+-dependent exocytotic secretionR01DK109979 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI LU, ZHE · 2016 to 2019
$1.6M
NIDDK NIH HHS R01 DK109979
6 · The paper itself

Abstract

Inhibitors targeting ion channels are useful tools for studying their functions. Given the selectivity of any inhibitor for a channel is relative, more than one inhibitor of different affinities may be used to help identify the channel in a biological preparation. Here, we describe a family of small proteins in centipede venoms that inhibit the pore (hKir6.2) of a human ATP-sensitive K

Indexed as

ArthropodsAnimalsArthropod VenomsChromatography, High Pressure LiquidHumansKcnj11 ChannelPotassium Channels, Inwardly RectifyingTranscriptomeArthropod VenomsKcnj11 ChannelPotassium Channels, Inwardly Rectifying

Identifiers

PMID31575961
PMCPMC6773964

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.