Evidence map›Paper›PMID 31575922›Full record

ArticleScientific reports2019

Scribble co-operatively binds multiple α

Eric M Janezic, Dorathy-Ann Harris, Diana Dinh, Kyung-Soon Lee, Aaron Stewart, Thomas R Hinds, Peter L Hsu, Ning Zheng, Chris Hague

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Introduction: A Short History of Adrenoceptor Research.Handbook of experimental pharmacology · 2024
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. N-glycosylation of αScientific reports · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eric M JanezicDepartment of Pharmacology, School of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195, USA.ORCID http://orcid.org/0000-0002-3177-889X
Dorathy-Ann HarrisDepartment of Pharmacology, School of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195, USA.
Diana DinhDepartment of Pharmacology, School of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195, USA.
Kyung-Soon LeeDepartment of Pharmacology, School of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195, USA.
Aaron StewartDepartment of Pharmacology, School of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195, USA.
Thomas R HindsDepartment of Pharmacology, School of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195, USA.
Peter L HsuDepartment of Pharmacology, School of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195, USA.
Ning ZhengDepartment of Pharmacology, School of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195, USA.ORCID http://orcid.org/0000-0002-1039-1581
Chris HagueDepartment of Pharmacology, School of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195, USA. chague@uw.edu.

Funding

Pharmacological Sciences SupplementT32GM007750 · NIGMS · UNIVERSITY OF WASHINGTON · PI ATKINS, WILLIAM M · 1985 to 2023
$12.6M
The a-catulin/dystrophin-associated protein complex regulates GPCR function.R01GM100893 · NIGMS · UNIVERSITY OF WASHINGTON · PI HAGUE, CHRIS S · 2012 to 2020
$2.9M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM100893NIGMS NIH HHS T32 GM007750
6 · The paper itself

Abstract

Many G protein-coupled receptors (GPCRs) are organized as dynamic macromolecular complexes in human cells. Unraveling the structural determinants of unique GPCR complexes may identify unique protein:protein interfaces to be exploited for drug development. We previously reported α

Indexed as

PDZ DomainsBinding SitesCrystallography, X-RayHEK293 CellsHumansImmunoprecipitationInterferometryMembrane ProteinsMolecular Docking SimulationReceptors, Adrenergic, alpha-1Structure-Activity RelationshipTumor Suppressor ProteinsADRA1D protein, humanMembrane ProteinsReceptors, Adrenergic, alpha-1SCRIB protein, humanTumor Suppressor Proteins

Identifiers

PMID31575922
PMCPMC6773690

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.