ArticleScientific reports2019
Non-cytotoxic hydroxyl-functionalized exfoliated boron nitride nanoflakes impair the immunological function of insect haemocytes in vivo.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Ytterbium-Zinc Oxide Embedded on Hexagonal Boron Nitride Nanocomposite for Electro-Oxidation of Ciprofloxacin.ChemistryOpen · 2025Article
- Emerging 2D Nanomaterials-Integrated Hydrogels: Advancements in Designing Theragenerative Materials for Bone Regeneration and Disease Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- In vivo study on borophene nanoflakes interaction with Tenebrio molitor beetle: viability of hemocytes and short-term immunity effect.Scientific reports · 2023Article
- The Influence of the Size of BN NSs on Silkworm Development and Tissue Microstructure.Nanomaterials (Basel, Switzerland) · 2023Article
- Graphene nanoplatelets and other 2D-materials as protective means against the fading of coloured inks, dyes and paints.Nanoscale · 2023Article
- Sustainable Synthesis of Highly Biocompatible 2D Boron Nitride Nanosheets.Biomedicines · 2022Article
- Recent Progress in Fabrication and Application of BN Nanostructures and BN-Based Nanohybrids.Nanomaterials (Basel, Switzerland) · 2022Review
- Multifunctionality of Nanosized Calcium Apatite Dual-Doped with LiBiomolecules · 2021Article
- Antipathogenic properties and applications of low-dimensional materials.Nature communications · 2021Review
- Assessment of Physico-Chemical and Toxicological Properties of Commercial 2D Boron Nitride Nanopowder and Nanoplatelets.International journal of molecular sciences · 2021Article
- The recent advancement of low-dimensional nanostructured materials for drug delivery and drug sensing application: A brief review.Journal of molecular liquids · 2020Review
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Authors and funding
6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
To induce the water solubility of hexagonal boron nitride (h-BN), we exfoliated and functionalized bulk h-BN with hydroxyl groups (h-BN-OH-n). Short-term studies showed that h-BN-OH-n induced low cytotoxicity in different models: insect haemocytes (in vivo), human erythrocytes and mouse fibroblasts (in vitro). We also demonstrated that Alexa Fluor 647-h-BN-OH-n administered topically to the insects passed through the cuticle barrier and was phagocytosed by haemocytes. Nanoflakes did not affect the haemocyte cell membrane and did not interfere with the phagocytosis of latex beads. Long-term immunoassays showed that h-BN-OH-n, despite not inducing haemocytotoxicity, impaired nodulation, the most important cellular immune response in insects. The haemocytes exposed to h-BN-OH-n and then to bacteria differed in morphology and adhesiveness from the haemocytes exposed only to bacteria and exhibited the same morphology and adhesiveness as the control haemocytes. The h-BN-OH-n-induced decrease in nodulation can therefore result from the reduced ability of haemocytes to recognize bacteria, migrate to them or form microaggregates around them, which can lead to dysfunction of the immune system during pathogen infection. Long-term in vivo studies with animal models are still necessary to unambiguously confirm that h-BN is biocompatible and useful for application as a platform for drug delivery or for bioimaging.
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