Evidence map›Paper›PMID 31575829›Full record

ArticleAging2019

Differential effects of extracellular vesicles from aging and young mesenchymal stem cells in acute lung injury.

Ruoqiong Huang, Chaojin Qin, Jiangmei Wang, Yaoqin Hu, Guoping Zheng, Guanguan Qiu, Menghua Ge, Huikang Tao, Qiang Shu, Jianguo Xu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 6 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 6 syntheses or guidelines pooled it, 146 citations in OpenAlex.

  1. Pooled it
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  11. Aging and lung diseases: Unraveling mechanisms and therapeutic targets.Chinese medical journal pulmonary and critical care medicine · 2025
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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ruoqiong HuangChildren's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310052, China.
Chaojin QinChildren's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310052, China.
Jiangmei WangChildren's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310052, China.
Yaoqin HuChildren's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310052, China.
Guoping ZhengShaoxing Second Hospital, Shaoxing, Zhejiang 312000, China.
Guanguan QiuShaoxing Second Hospital, Shaoxing, Zhejiang 312000, China.
Menghua GeShaoxing Second Hospital, Shaoxing, Zhejiang 312000, China.
Huikang TaoChildren's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310052, China.
Qiang ShuChildren's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310052, China.
Jianguo XuShaoxing Second Hospital, Shaoxing, Zhejiang 312000, China.
Children's Hospital of Zhejiang University · CNShaoxing Second Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Old age is a known risk factor for mortality in acute respiratory distress syndrome (ARDS)/acute lung injury. Mesenchymal stem cells (MSCs) possess potent immunomodulatory properties, while aging MSCs have reduced capacity. Recent studies have demonstrated that MSC-derived extracellular vesicles (MSC-EVs) are able to mimic MSCs in alleviating acute lung injury. The goals of this study were to determine whether EVs from young and aging MSCs had differential effects on lipopolysaccharide (LPS)-induced lung injury in young mice and unravel the underlying mechanisms. Our results showed that both aging and young MSC-EVs had similar physical and phenotypical properties. As their parental cells, young MSC-EVs alleviated LPS-induced acute lung injury, while aging MSC-EVs did not exhibit the protective effects. In contrast to young MSC-EVs, aging MSC-EVs failed to alter macrophage phenotypes and reduce macrophage recruitment. In addition, the internalization of aging MSC-EVs by macrophages was significantly lower compared with that of young MSC-EVs. Furthermore, aging and young MSC-EVs differed in levels of several miRNAs relating macrophage polarization. In conclusion, aging and young MSC-EVs have differential effects in alleviating acute lung injury and macrophage polarization, which may be associated with internalization of EVs and their miRNA content.

Indexed as

Mesenchymal Stem Cell TransplantationAcute Lung InjuryAge FactorsAnimalsDisease Models, AnimalExtracellular VesiclesMesenchymal Stem CellsMiceTreatment Outcomeacute lung injuryagingARDSextracellular vesiclesmesenchymal stem cells

Identifiers

PMID31575829
PMCPMC6781978
OpenAlexW2976973875

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.