Evidence map›Paper›PMID 31575772›Full record

ArticlemBio2019

Increased Epithelial Oxygenation Links Colitis to an Expansion of Tumorigenic Bacteria.

Stephanie A Cevallos, Jee-Yon Lee, Connor R Tiffany, Austin J Byndloss, Luana Johnston, Mariana X Byndloss, Andreas J Bäumler

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 72 citations in OpenAlex.

  1. Microbiota-derived indole limitsScience advances · 2026
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  6. Infection strategies ofGut microbes reports · 2026
    Review
  7. Review
  8. ComparingGut microbes · 2025
    Article
  9. Article
  10. Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Bacterial membrane vesicles restore gut anaerobiosis.NPJ biofilms and microbiomes · 2025
    Article
  17. Guided Multispectral Optoacoustic Tomography for 3D Imaging of the Murine Colon.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Stephanie A CevallosDepartment of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, California, USA.
Jee-Yon LeeDepartment of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, California, USA.
Connor R TiffanyDepartment of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, California, USA.ORCID 0000-0001-8188-7720
Austin J ByndlossDepartment of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, California, USA.
Luana JohnstonDepartment of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, California, USA.
Mariana X Byndloss *Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, California, USA.
Andreas J Bäumler *Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, California, USA ajbaumler@ucdavis.edu.
University of California, Davis · US

Funding

UC Davis Biology ProgramR25GM056765 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI GOMES, ALDRIN V. · 1998 to 2019
$9.7M
Virulence Factors of SalmonellaR01AI044170 · NIAID · UNIVERSITY OF CALIFORNIA DAVIS · PI BAUMLER, ANDREAS J · 1999 to 2022
$8.5M
Undergraduate Biomedical Research Training at HunterT34GM007823 · NIGMS · HUNTER COLLEGE · PI FORD, JENNIFER S · 1985 to 2020
$8.2M
Exacerbation of colitis by the microbiotaR01AI112445 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Andreas J Baumler · 2015 to 2026
$6.2M
Microbiota Outgrowth by SalmonellaR01AI096528 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BAUMLER, ANDREAS J · 2011 to 2025
$6.1M
University of Michigan Postbaccalaureate Research Education Program (UM PREP)R25GM086262 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALLEN, BENJAMIN · 2009 to 2024
$6.1M
Mechanism of Colonization ResistanceR01AI112949 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Andreas J Baumler · 2016 to 2026
$5.2M
Mechanism of E. coli colonization resistanceR56AI112949 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BAUMLER, ANDREAS J · 2014 to 2014
$382k
NIAID NIH HHS R01 AI044170NIAID NIH HHS R01 AI096528NIAID NIH HHS R01 AI112445NIAID NIH HHS R01 AI112949NIAID NIH HHS R56 AI112949NIGMS NIH HHS R25 GM056765NIGMS NIH HHS R25 GM086262NIGMS NIH HHS T34 GM007823
6 · The paper itself

Abstract

Intestinal inflammation is a risk factor for colorectal cancer formation, but the underlying mechanisms remain unknown. Here, we investigated whether colitis alters the colonic microbiota to enhance its cancer-inducing activity. Colitis increased epithelial oxygenation in the colon of mice and drove an expansion of

Indexed as

CarcinogenesisGastrointestinal MicrobiomeAerobiosisAnimalsColitisColorectal NeoplasmsDextran SulfateEscherichia coliEscherichia coli InfectionsFemaleMiceMice, Inbred C57BLOxygenPeptidesPolyketidescolibactinDextran SulfateOxygenPeptidesPolyketidescolibactincolorectal cancerEscherichia colimicrobiome

Identifiers

PMID31575772
PMCPMC6775460
OpenAlexW2978795779

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.