Evidence map›Paper›PMID 31575771›Full record

ArticlemBio2019

Pseudomonas aeruginosa Quorum Sensing Molecule Alters Skeletal Muscle Protein Homeostasis by Perturbing the Antioxidant Defense System.

Arunava Bandyopadhaya, A Aria Tzika, Laurence G Rahme

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Frontiers in immunology · 2026
    Article
  5. Revealing the impact ofFrontiers in immunology · 2025
    Article
  6. Frontiers in immunology · 2025
    Review
  7. Article
  8. Article
  9. Mechanisms of the Quorum Sensing Systems ofCurrent medicinal chemistry · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Arunava BandyopadhayaDepartment of Surgery, Center for Surgery, Innovation and Bioengineering, Massachusetts General Hospital, Harvard Medical School Boston, Massachusetts, USA.
A Aria TzikaDepartment of Surgery, Center for Surgery, Innovation and Bioengineering, Massachusetts General Hospital, Harvard Medical School Boston, Massachusetts, USA.
Laurence G RahmeDepartment of Surgery, Center for Surgery, Innovation and Bioengineering, Massachusetts General Hospital, Harvard Medical School Boston, Massachusetts, USA rahme@molbio.mgh.harvard.edu.
Harvard University · USMassachusetts General Hospital · USShriners Hospitals for Children - Boston · US

Funding

Molecular and Metabolic inter-kingdom actions of a bacterial quorum sensing signal in promotion of host tolerance/resilience.R01AI134857 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RAHME, LAURENCE G · 2018 to 2022
$3.4M
NIAID NIH HHS R01 AI134857
6 · The paper itself

Abstract

Skeletal muscle function is compromised in many illnesses, including chronic infections. The

Indexed as

Quorum SensingAcetylcysteineAnimalsAntioxidantsCells, CulturedMaleMiceMuscle Fibers, SkeletalMuscle ProteinsMuscle, SkeletalNADPPseudomonas aeruginosaPseudomonas InfectionsReactive Oxygen SpeciesTranscription FactorsUncoupling Protein 3AcetylcysteineAntioxidantsMuscle ProteinsNADPperoxisome-proliferator-activated receptor-gamma coactivator-1Reactive Oxygen SpeciesTranscription FactorsUcp3 protein, mouseUncoupling Protein 3Xanthine Oxidase2-amino acetophenone (2-AA)chronic infectionsmuscle atrophymuscle dysfunctionNAD(P)H oxidase 2 (NOX2)Pseudomonas aeruginosaquorum sensing (QS)reactive oxygen species (ROS)skeletal musclevirulencexanthine oxidase (XO)

Identifiers

PMID31575771
PMCPMC6775459
OpenAlexW2978593474

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.