Evidence map›Paper›PMID 31575658›Full record

ArticleThe Journal of biological chemistry2019

Brassicaceae-specific Gretchen Hagen 3 acyl acid amido synthetases conjugate amino acids to chorismate, a precursor of aromatic amino acids and salicylic acid.

Cynthia K Holland, Corey S Westfall, Jason E Schaffer, Alejandro De Santiago, Chloe Zubieta, Sophie Alvarez, Joseph M Jez

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
6.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Emergence of isochorismate-based salicylic acid biosynthesis within Brassicales.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Arabidopsis GH3.10 conjugates jasmonates.Plant biology (Stuttgart, Germany) · 2025
    Article
  7. Review
  8. Review
  9. Chemical genetic screening identifies nalacin as an inhibitor of GH3 amido synthetase for auxin conjugation.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  10. Chemical inhibition of the auxin inactivation pathway uncovers the roles of metabolic turnover in auxin homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  11. Article
  12. Review
  13. Article
  14. ABI3 plays a role inPlant signaling & behavior · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Cynthia K HollandDepartment of Biology, Washington University, St. Louis, Missouri 63130.
Corey S WestfallDepartment of Biology, Washington University, St. Louis, Missouri 63130.
Jason E SchafferDepartment of Biology, Washington University, St. Louis, Missouri 63130.
Alejandro De SantiagoDepartment of Biology, Washington University, St. Louis, Missouri 63130.
Chloe ZubietaLaboratoire de Physiologie Cellulaire & Végétale, University Grenoble Alpes, CNRS, CEA, INRA, IRIG, Grenoble, France.
Sophie AlvarezDepartment of Agronomy and Horticulture, University of Nebraska-Lincoln, Lincoln, Nebraska 68583.
Joseph M JezDepartment of Biology, Washington University, St. Louis, Missouri 63130 jjez@wustl.edu.
Washington University in St. Louis · USCEA Grenoble · FRUniversity of Nebraska–Lincoln · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To modulate responses to developmental or environmental cues, plants use Gretchen Hagen 3 (GH3) acyl acid amido synthetases to conjugate an amino acid to a plant hormone, a reaction that regulates free hormone concentration and downstream responses. The model plant

Indexed as

Amino Acids, AromaticArabidopsisBrassicaceaeCatalytic DomainChorismic AcidKineticsLigasesModels, MolecularMutationSalicylic AcidSpecies SpecificitySubstrate SpecificityAmino Acids, AromaticChorismic AcidLigasesSalicylic AcidArabidopsis thalianaenzymeplant biochemistrysubstrate specificityX-ray crystallography

Identifiers

PMID31575658
PMCPMC6851337
OpenAlexW2977812363

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.