Evidence map›Paper›PMID 31575621›Full record

ArticleMolecular pharmacology2019

Homologous Regulation of Mu Opioid Receptor Recycling by G

Jennifer M Kunselman, Amanda S Zajac, Zara Y Weinberg, Manojkumar A Puthenveedu

Open access · bronzeAbstract read
In one paragraph

Article in Molecular pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
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  9. Article
  10. Opioid Pharmacology under the Microscope.Molecular pharmacology · 2020
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jennifer M KunselmanCellular and Molecular Biology Program (J.M.K., M.A.P.) and Department of Pharmacology (J.M.K., Z.Y.W., M.A.P.), University of Michigan, Ann Arbor, Michigan; and Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania (A.S.Z., M.A.P.).ORCID 0000-0002-9772-4149
Amanda S ZajacCellular and Molecular Biology Program (J.M.K., M.A.P.) and Department of Pharmacology (J.M.K., Z.Y.W., M.A.P.), University of Michigan, Ann Arbor, Michigan; and Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania (A.S.Z., M.A.P.).
Zara Y WeinbergCellular and Molecular Biology Program (J.M.K., M.A.P.) and Department of Pharmacology (J.M.K., Z.Y.W., M.A.P.), University of Michigan, Ann Arbor, Michigan; and Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania (A.S.Z., M.A.P.).ORCID 0000-0001-7176-038X
Manojkumar A PuthenveeduCellular and Molecular Biology Program (J.M.K., M.A.P.) and Department of Pharmacology (J.M.K., Z.Y.W., M.A.P.), University of Michigan, Ann Arbor, Michigan; and Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania (A.S.Z., M.A.P.) puthenve@umich.edu.ORCID 0000-0002-3177-4231
University of Michigan · US

Funding

CELLULAR AND MOLECULAR BIOLOGY AT MICHIGANT32GM007315 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTHENVEEDU, MANOJKUMAR A · 1985 to 2021
$12.8M
MECHANISMS ENSURING SEQUENCE-DEPENDENT GPCR RECYCLINGR01GM117425 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTHENVEEDU, MANOJKUMAR A · 2016 to 2020
$1.5M
NIGMS NIH HHS R01 GM117425NIGMS NIH HHS T32 GM007315
6 · The paper itself

Abstract

Membrane trafficking and receptor signaling are two fundamental cellular processes that interact constantly. Although how trafficking regulates signaling is well studied, how signaling pathways regulate trafficking is less well understood. Here, we use the mu opioid receptor (MOR), the primary target for opioid analgesics, to define a signaling pathway that dynamically regulates postendocytic receptor recycling. By directly visualizing individual MOR recycling events, we show that agonist increases MOR recycling. Inhibition of G

Indexed as

Analgesics, OpioidEndocytosisEnkephalin, Ala(2)-MePhe(4)-Gly(5)-GTP-Binding Protein beta SubunitsGTP-Binding Protein gamma SubunitsHEK293 CellsHumansPhosphorylationProtein Kinase CReceptors, Opioid, muAnalgesics, OpioidEnkephalin, Ala(2)-MePhe(4)-Gly(5)-GTP-Binding Protein beta SubunitsGTP-Binding Protein gamma SubunitsProtein Kinase CReceptors, Opioid, mu

Identifiers

PMID31575621
PMCPMC6820217
OpenAlexW2977891708

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.