ArticleBMJ open2019
Neurodevelopmental disorders among term infants exposed to antenatal corticosteroids during pregnancy: a population-based study.
Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 5 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 5 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Epigenetic effects of endogenous and exogenous glucocorticosteroids during pregnancy on the offspring: a systematic-narrative review.Hormones (Athens, Greece) · 2025Pooled it
- The proportions of term or late preterm births after exposure to early antenatal corticosteroids, and outcomes: systematic review and meta-analysis of 1.6 million infants.BMJ (Clinical research ed.) · 2023Pooled it
- Evaluation of Long-term Outcomes Associated With Preterm Exposure to Antenatal Corticosteroids: A Systematic Review and Meta-analysis.JAMA pediatrics · 2022Pooled it
- Antenatal corticosteroids prior to planned caesarean at term for improving neonatal outcomes.The Cochrane database of systematic reviews · 2021Pooled it
- Fetal Diagnosis and Therapy during the COVID-19 Pandemic: Guidance on Behalf of the International Fetal Medicine and Surgery Society.Fetal diagnosis and therapy · 2020Guideline
- Dogmas in Obstetrics: Evidence-Based Standards, Clinical Judgement and Patient-Centred Care.Geburtshilfe und Frauenheilkunde · 2026Article
- Antenatal Corticosteroids: Short-Term Gains, Long-Term Questions-A Meta-Analysis.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Revisiting the safety of short-term systemic corticosteroids.Biomedical journal · 2026Review
- Prenatal exposure to maternal asthma and asthma medication and neurodevelopmental outcomes: a population cohort study of 179,024 children.BMC medicine · 2026Article
- Maternal urinary metabolomic signatures preceding spontaneous preterm birth: A pilot study.Scientific reports · 2025Article
- Mid-pregnancy uterine artery Dopplers and child neurodevelopment.Pregnancy (Hoboken, N.J.) · 2025Article
- Associations of Antenatal Corticosteroids With Neurodevelopment in Children Aged 27-30 Months: A Population-Based Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- The influence of antenatal betamethasone timing on neonatal outcome in late preterm infants: a single-center cohort study.Archives of gynecology and obstetrics · 2025Article
- Timing of antenatal corticosteroid exposure and its association with childhood mental disorders in early- and full-term births: A population-based cohort study.European journal of pediatrics · 2025Article
- Impact of corticosteroid exposure on preterm labor in neonates eventually born at term.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Antenatal corticosteroids and outcomes of small for gestational age infants born at 24-31 gestational weeks: a population-based propensity score matching analysis.Archives of gynecology and obstetrics · 2023Article
- Timing of antenatal steroid administration for imminent preterm birth: results of a prospective observational study in Germany.Archives of gynecology and obstetrics · 2023Observational
- An update on the long-term outcomes of prenatal dexamethasone treatment in congenital adrenal hyperplasia.Endocrine connections · 2023Review
- Genomic glucocorticoid action in embryonic mouse neural stem cells.Molecular and cellular endocrinology · 2023Article
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Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAn increasing proportion of fetuses are exposed to antenatal corticosteroids (ACS). Despite their immediate beneficial effects, the long-term safety of ACS has been an ongoing source of concern. In the current study, we assessed the likelihood of neurodevelopmental problems among term infants exposed to ACS earlier in pregnancy compared with non-exposed term infants.
designRetrospective cohort study (2006-2011). Median duration of follow-up was 7.8 (IQR 6.4-9.2) years.
settingPopulation-based study, Ontario, Canada.
participantsAll live singleton infants born at term (≥37 EXPOSURE: ACS during pregnancy. PRIMARY AND SECONDARY OUTCOME MEASURES: A composite of diagnostic or billing codes reflecting proven or suspected neurodevelopmental problems during childhood including audiometry testing, visual testing or physician service claim with a diagnosis code related to a suspected neurocognitive disorder.
resultsAt 5 years of age, the cumulative rate for the primary outcome was higher among infants exposed to ACS compared with non-exposed infants: 61.7% (3346/5423) vs 57.8% (302 520/523 782), respectively (p<0.001; number needed to harm (NNH)=25, 95% CI 19 to 38; adjusted HR (aHR) 1.12, 95% CI 1.08 to 1.16). Similar findings were observed for each of the individual components of the primary outcome: 15.3% vs 12.7% for audiometry testing (p<0.001; NNH=39, 95% CI 29 to 63; aHR 1.18, 95% CI 1.11 to 1.25); 45.4% vs 43.5% for visual testing (p=0.006; NNH=54, 95% CI 31 to 200; aHR 1.08, 95% CI 1.04 to 1.12) and 25.8% vs 21.6% for suspected neurocognitive disorder (p<0.001; NNH=24, 95% CI 19 to 33; aHR 1.16, 95% CI 1.10 to 1.21).
conclusionsWe found an association among term infants between exposure to ACS during pregnancy and healthcare utilisation during childhood related to suspected neurocognitive and neurosensory disorders.
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