ArticleThe American journal of cardiology2019
Resting Heart Rate, Short-Term Heart Rate Variability and Incident Atrial Fibrillation (from the Multi-Ethnic Study of Atherosclerosis (MESA)).
Article in The American journal of cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 52 citations in OpenAlex.
- Autonomic Nervous Dysfunction and Ultra-Short-Term Heart Rate Variability in Atrial Fibrillation: Recent Advances in Early Detection.Journal of cardiovascular development and disease · 2026Review
- Atrial cardiomyopathy as a multidomain disease: longitudinal evidence for autonomic remodelling.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Article
- Relationships Between Adiposity Measures and Heart Rate Variability in Children and Adolescents.Pediatric cardiology · 2026Article
- Pulse Rate Variability and All-Cause Mortality Risk in the General Japanese Population.Circulation reports · 2026Article
- Heart rate variability in patients with atrial fibrillation of sinus rhythm or atrial fibrillation: chaos or merit?Annals of medicine · 2025Review
- Nocturnal Heart Rate Variability in Unexplained Syncope and Sleep Apnea-The SINCOSAS Study.Journal of clinical medicine · 2025Article
- Article
- Association between heart rate fragmentation and kidney function decline in MESA: evidence consistent with parasympathetic degradation.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- A PPG Signal Dataset Collected in Semi-Naturalistic Settings Using Galaxy Watch.Scientific data · 2025Article
- Assessing heart rate fragmentation to predict atrial fibrillation in the general population aged 65: the PROOF-AF study.European heart journal open · 2025Article
- Heart rate variability in cardiovascular disease diagnosis, prognosis and management.Frontiers in cardiovascular medicine · 2025Review
- Exploring the impact of electrocardiographic parameters on the risk of common arrhythmias: a two-sample Mendelian randomization study.Journal of thoracic disease · 2024Article
- Heart Rate Variability and Cognition: A Narrative Systematic Review of Longitudinal Studies.Journal of clinical medicine · 2024Review
- The impact of visit-to-visit heart rate variability on all-cause mortality in atrial fibrillation.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2024Article
- Long-term association of ultra-short heart rate variability with cardiovascular events.Scientific reports · 2023Article
- Heart rate variability and atrial fibrillation in the general population: a longitudinal and Mendelian randomization study.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Article
- Resting heart rate and risk of atrial fibrillation in Chinese general population: Kailuan prospective cohort study.BMJ open · 2023Observational
- [Resting heart rate correlates with major adverse cardiovascular and cerebrovascular events in patients with post-myocardial infarction ventricular aneurysms: a retrospective cohort study].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- Development and validation of a nomogram for predicting atrial fibrillation in patients with acute heart failure admitted to the ICU: a retrospective cohort study.BMC cardiovascular disorders · 2022Article
- Article
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9 authors at 7 institutions in 1 country.
Funding
Abstract
Evidence suggests an association between autonomical nervous system (ANS) function and atrial fibrillation (AF) development. We sought to examine the association of baseline resting heart rate (RHR) and short-term heart rate variability (HRV) as surrogates of (ANS) with incident AF in individuals without previous cardiovascular disease. A total of 6,261 participants of the Multi-Ethnic Study of Atherosclerosis who were free of AF and diagnosed cardiovascular disease were enrolled. Three standard 10-second, 12-lead electrocardiograms (ECG) were used to measure RHR, the standard deviation of normal-to-normal intervals (SDNN) and the root mean square of successive differences in RR intervals (RMSSD). Cox proportional hazards models adjusted for demographics, atrioventricular nodal agents, and known cardiovascular risk factors were used to examine the association of baseline RHR, and log transformed SDNN and RMSDD with incident AF. Over a mean follow-up of 11.3 ± 3.7 years, 754 (12%) participants developed AF. Spline curve analysis revealed a nonlinear association between RHR, HRV, and incident AF. In fully adjusted models higher (but not lower) baseline RHR (RHR >76 beats/min) was associated with incident AF (hazard ratio 1.48 95% confidence interval 1.18 to 1.86). Additionally, lower values of RMSDD and SDNN and higher values of RMSDD were independently associated with incident AF. In conclusion, cardiac ANS dysregulation indicated as higher RHR and lower HRV is associated with incident AF independent of known cardiovascular risk factors.
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