Evidence map›Paper›PMID 31575336›Full record

Trial reportJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2020

Different preprocessing strategies lead to different conclusions: A [

Martin Nørgaard, Melanie Ganz, Claus Svarer, Vibe G Frokjaer, Douglas N Greve, Stephen C Strother, Gitte M Knudsen

Open access · bronzeAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Building an open infrastructure for molecular neuroimaging: Standards and tools from the OpenNeuroPET initiative.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  2. Article
  3. Article
  4. An In Vivo High-Resolution Human Brain Atlas of Synaptic Density.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  5. Article
  6. An automatic analysis framework for FDOPA PET neuroimaging.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  7. Review
  8. Article
  9. Imaging Histamine H3 Receptors with Positron Emission Tomography.Current topics in behavioral neurosciences · 2022
    Review
  10. Reproducibility of findings in modern PET neuroimaging: insight from the NRM2018 grand challenge.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Martin NørgaardNeurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0003-2131-5688
Melanie GanzNeurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Claus SvarerNeurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Vibe G FrokjaerNeurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Douglas N GreveAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Stephen C StrotherRotman Research Institute, Baycrest, Department of Medical Biophysics, University of Toronto, Toronto, Canada.
Gitte M KnudsenNeurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
University of Copenhagen · DKCopenhagen University Hospital · DKHarvard University · USUniversity of Toronto · CA

Funding

FreeSurfer Development, Maintenance, and HardeningR01EB023281 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Bruce Fischl, Douglas Nowlin Greve · 2016 to 2026
$5.6M
A Longitudinal Analysis Stream for FreeSurferR01NS083534 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Bruce Fischl · 2014 to 2026
$4.6M
Segmenting Brain Structures for Neurological DisordersR01NS105820 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Bruce Fischl · 2019 to 2026
$3.2M
Algorithms for MR and OCT-based Architectonic and Laminar SegmentationR01EB019956 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI FISCHL, BRUCE · 2015 to 2018
$2.4M
Multimodal brain imaging of serotoninR21EB018964 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI GREVE, DOUGLAS NOWLIN, KNUDSEN, GITTE MOOS · 2014 to 2015
$423k
NIBIB NIH HHS R01 EB019956NIBIB NIH HHS R01 EB023281NIBIB NIH HHS R21 EB018964NINDS NIH HHS R01 NS083534NINDS NIH HHS R01 NS105820
6 · The paper itself

Abstract

Positron emission tomography (PET) neuroimaging provides unique possibilities to study biological processes in vivo under basal and interventional conditions. For quantification of PET data, researchers commonly apply different arrays of sequential data analytic methods ("preprocessing pipeline"), but it is often unknown how the choice of preprocessing affects the final outcome. Here, we use an available data set from a double-blind, randomized, placebo-controlled [

Indexed as

AdultArtifactsBenzylaminesDepressionDouble-Blind MethodFemaleGonadal Steroid HormonesHead MovementsHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingModels, NeurologicalNeocortexNeurotic DisordersPositron-Emission TomographyRadiopharmaceuticalsBenzylaminesGonadal Steroid HormonesN,N-dimethyl-2-(2-amino-4-cyanophenylthio)benzylamineRadiopharmaceuticalsSerotonin Plasma Membrane Transport Proteinshead motionkinetic modelingpartial volume correctionPositron emission tomographypreprocessing

Identifiers

PMID31575336
PMCPMC7446563
OpenAlexW2977322611

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.