Evidence map›Paper›PMID 31574961›Full record

ReviewCancers2019

The Role of TRAIL/DRs in the Modulation of Immune Cells and Responses.

Duygu Sag, Zeynep Ozge Ayyildiz, Sinem Gunalp, Gerhard Wingender

Abstract readReview
In one paragraph

Review in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Article
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  3. A single-cell cytokine dictionary of human peripheral blood.bioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Duygu SagIzmir Biomedicine and Genome Center (IBG), 35340 Balcova/Izmir, Turkey. duygu.sag@ibg.edu.tr.
Zeynep Ozge AyyildizDepartment of Genome Sciences and Molecular Biotechnology, Izmir International Biomedicine and Genome Institute, Dokuz Eylul University, 35340 Balcova/Izmir, Turkey. zeynepozge.ayyildiz@ogr.deu.edu.tr.
Sinem GunalpDepartment of Genome Sciences and Molecular Biotechnology, Izmir International Biomedicine and Genome Institute, Dokuz Eylul University, 35340 Balcova/Izmir, Turkey. sinem.gunalp@ogr.deu.edu.tr.
Gerhard WingenderIzmir Biomedicine and Genome Center (IBG), 35340 Balcova/Izmir, Turkey. gerhard.wingender@ibg.edu.tr.ORCID 0000-0002-7115-298X

Funding

H2020 Marie Skłodowska-Curie Actions 777995TUBITAK 118Z363TUBITAK 118Z997
6 · The paper itself

Abstract

Expression of TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) by immune cells can lead to the induction of apoptosis in tumor cells. However, it becomes increasingly clear that the interaction of TRAIL and its death receptors (DRs) can also directly impact immune cells and influence immune responses. Here, we review what is known about the role of TRAIL/DRs in immune cells and immune responses in general and in the tumor microenvironment in particular.

Indexed as

apoptosisimmune regulationlymphoid cellsmyeloid cellstumor

Identifiers

PMID31574961
PMCPMC6826877

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.