ArticleMolecules (Basel, Switzerland)2019
Biological Effects of Shikonin in Human Gingival Fibroblasts via ERK 1/2 Signaling Pathway.
Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Shikonin promotes osteogenic differentiation of periodontal ligament stem cells by modulating the p38 MAPK/ETS transcription factor 1/cementum protein 1 axis in vitro.Journal of cell communication and signaling · 2026Article
- Volatile Natural Deep Eutectic Solvents (VNADESs) for Extraction of Shikonin Derivatives fromMolecules (Basel, Switzerland) · 2026Article
- Phytochemicals in Treatment of Periodontal Disease: A Review of Mechanisms and Roles.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- Pharmacological Effects of Shikonin and Its Potential in Skin Repair: A Review.Molecules (Basel, Switzerland) · 2023Review
- Shikonin improves pulmonary vascular remodeling in monocrotaline‑induced pulmonary arterial hypertension via regulation of PKM2.Molecular medicine reports · 2023Article
- PLA-HPG based coating enhanced anti-biofilm and wound healing of Shikonin in MRSA-infected burn wound.Frontiers in bioengineering and biotechnology · 2023Article
- Botanical Drugs in Traditional Chinese Medicine With Wound Healing Properties.Frontiers in pharmacology · 2022Review
- Shikonin protects against lipopolysaccharide-induced inflammation and apoptosis in human nucleus pulposus cells through the nuclear factor-kappa B pathway.Food science & nutrition · 2021Article
- Electrospun wound dressings containing bioactive natural products: physico-chemical characterization and biological assessment.Biomaterials research · 2021Article
- Differential microbial assemblages associated with shikonin-producing Borage species in two distinct soil types.Scientific reports · 2021Article
- The Role of PKM2 in Metabolic Reprogramming: Insights into the Regulatory Roles of Non-Coding RNAs.International journal of molecular sciences · 2021Review
- Traditional Chinese Medicine is an Alternative Therapeutic Option for Treatment ofFrontiers in pharmacology · 2021Review
- Shikonin suppresses the epithelial-to-mesenchymal transition by downregulating NHE1 in bladder cancer cells.Journal of Cancer · 2021Article
- Targeting periodontitis with shikonin: Molecular insights and therapeutic prospects - A narrative review.Journal of Indian Society of PeriodontologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Shikonin, an active ingredient of
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.